Zhang Juncheng
Department of Gynecology, Gansu Maternal and Child Health Care Hospital (Gansu Provincial Central Hospital), Lanzhou, CHN.
Department of Gynecology, Gansu University of Traditional Chinese Medicine, Lanzhou, CHN.
Cureus. 2025 Jun 29;17(6):e86968. doi: 10.7759/cureus.86968. eCollection 2025 Jun.
Intrauterine adhesions (IUA) are a common gynecologic disorder usually caused by infection, surgery, or trauma. Its pathogenesis is complex and involves multiple factors such as cytokines, inflammatory responses, and tissue fibrosis. In recent years, diagnostic and therapeutic options for uterine adhesions have evolved, encompassing both traditional surgical methods and emerging biologic therapies. Platelet-rich plasma (PRP) therapy has gradually gained widespread attention in the field of obstetrics and gynecology. Its core concept is to utilize the abundant platelets in the patient's own blood to promote tissue repair and regeneration. The application of PRP by intrauterine instillation or injection can effectively improve endometrial thickness, enhance its receptivity, and subsequently improve pregnancy outcomes. In this paper, we report the case of a 33-year-old female patient who underwent hysterectomy for uterine remnants following a medical abortion. She subsequently developed secondary IUA, presenting as decreased menstrual flow. She initially received hysteroscopic cold knife adhesion separation combined with hormone replacement therapy, which proved ineffective. She later underwent repeat hysteroscopic cold knife adhesiolysis followed by intrauterine perfusion of PRP. After this intervention, her menstrual flow returned to normal, and she successfully conceived and delivered a healthy baby one year later.
宫腔粘连（IUA）是一种常见的妇科疾病，通常由感染、手术或创伤引起。其发病机制复杂，涉及细胞因子、炎症反应和组织纤维化等多种因素。近年来，宫腔粘连的诊断和治疗方法不断发展，涵盖了传统手术方法和新兴的生物疗法。富血小板血浆（PRP）疗法在妇产科领域逐渐受到广泛关注。其核心概念是利用患者自身血液中丰富的血小板来促进组织修复和再生。通过宫腔内滴注或注射应用PRP可有效增加子宫内膜厚度，提高其容受性，进而改善妊娠结局。在本文中，我们报告了一例33岁女性患者的病例，该患者在药物流产后因残留子宫组织接受了子宫切除术。随后她发生了继发性宫腔粘连，表现为月经量减少。她最初接受了宫腔镜冷刀粘连分离术联合激素替代疗法，但效果不佳。后来她再次接受了宫腔镜冷刀粘连松解术，随后进行了宫腔内PRP灌注。经过此次干预，她的月经量恢复正常，一年后成功受孕并产下一名健康婴儿。
