Luo Yu, Zhu Lin, Ren Zhengyu, Xiao Jian, Hao Erwei, Lu Jiahong, Zhao Jinmin, Yao Chun, Wang Yitao, Luo Hua
Macau Centre for Research and Development in Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.
Guangxi University of Chinese Medicine, Nanning 530001, China.
Chin Herb Med. 2025 Apr 24;17(3):428-447. doi: 10.1016/j.chmed.2025.04.006. eCollection 2025 Jul.
, derived from the rhizome of , and , was called Ezhu in China. In the past, extracts were obtained through water decoction or alternative methods, which showed significant anti-cancer effects. However, the mixed extracts contain various compound components of , leading to an ambiguous mechanism of action for extracts anti-cancer. Contemporary researchers have extracted the chemical components of separately for experimental verification of its active ingredients in the anti-cancer field. Numerous studies demonstrated that curcumol, germacrone, -elemene, and curcumin in extracts have significant governing effects in anti-cancer activities. Pharmacological studies have shown that suppresses cancer cell proliferation, invasion, and migration, triggering apoptosis and regulating cellular autophagy to achieve anticancer effects. Here, we summarized the research progress of on anti-cancer effects from 2013 to 2022, aiming to explore the deeper molecular mechanisms of 's active components in cancer treatment.
源自[植物名称1]、[植物名称2]和[植物名称3]的根茎，在中国被称为莪术。过去，莪术提取物是通过水煎或其他方法获得的，显示出显著的抗癌作用。然而，混合提取物含有莪术的各种化合物成分，导致莪术提取物抗癌的作用机制不明确。当代研究人员已分别提取莪术的化学成分，以在抗癌领域对其活性成分进行实验验证。大量研究表明，莪术提取物中的莪术醇、吉马酮、β-榄香烯和姜黄素在抗癌活性方面具有显著的调控作用。药理学研究表明，莪术可抑制癌细胞的增殖、侵袭和迁移，引发细胞凋亡并调节细胞自噬以实现抗癌效果。在此，我们总结了2013年至2022年莪术在抗癌作用方面的研究进展，旨在探索莪术活性成分在癌症治疗中更深层次的分子机制。
