Yin Minzhen, Yang Mei, Han Xiaojing, Yin Liwei, Peng Huasheng, Huang Luqi
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijng 100700, China.
Key Scientific Research Base of Traditional Chinese Medicine Heritage (Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences), National Cultural Heritage Administration, Beijng 100700, China.
Food Chem X. 2025 Jul 17;29:102802. doi: 10.1016/j.fochx.2025.102802. eCollection 2025 Jul.
(Schw.) Wolf () is valued for its nutritional and therapeutic properties. is commonly processed into slices of different shapes and sizes. We quantified alkali-soluble and water-soluble polysaccharides, total amino acids, and triterpenoids in slices of varying geometries (square: 1-9 cm width; round: 1-6 cm radii). Results showed that triterpenes and water-soluble polysaccharides initially decreased and then stabilized with increasing slice size, while total amino acids accumulated progressively, indicating spatial metabolic heterogeneity in . To map metabolite distribution, we segmented the into seven concentric zones and profiled the metabolites using a widely targeted metabolomics approach. A total of 359 metabolites were identified. The fungal symbiotic matrix exhibited metabolic profiles similar to the intermediate regions, while peripheral regions maintained comparable levels of triterpenes, saccharides, and amino acid derivatives. This study provides a detailed metabolomic blueprint of and offers insights for standardized processing and optimized medicinal use.
（施魏因富特）沃尔夫（）因其营养和治疗特性而受到重视。通常被加工成不同形状和大小的切片。我们对不同几何形状（方形：宽度1 - 9厘米；圆形：半径1 - 6厘米）的切片中的碱溶性和水溶性多糖、总氨基酸和三萜类化合物进行了定量。结果表明，随着切片尺寸的增加，三萜类化合物和水溶性多糖最初减少，然后稳定下来，而总氨基酸则逐渐积累，表明在切片中存在空间代谢异质性。为了绘制代谢物分布图，我们将切片分为七个同心区域，并使用广泛靶向代谢组学方法对代谢物进行分析。共鉴定出359种代谢物。真菌共生基质的代谢谱与中间区域相似，而外围区域的三萜类化合物、糖类和氨基酸衍生物水平相当。本研究提供了详细的代谢组学蓝图，并为标准化加工和优化药用提供了见解。
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