Spacek J
Anat Embryol (Berl). 1985;173(1):129-35. doi: 10.1007/BF00707311.
A total of 80 cotical axo-spinous synaptic junctions were reconstructed from serial sections and about 100,000 were analyzed in single sections. Special attention was paid to the occurrence of puncta adhaerentia associated with perforated, annulate or horseshoe-shaped (= complex) synaptic junctions and to the presence and proximity of the spine apparatus. Further evidence is presented that the spine apparatus has no relationship to simple (round or oval) synaptic specializations, but is present in association with at least 91% of complex junctions. The spine apparatus points towards the punctum adhaerens which in at least 71% of cases seems to be an integral part of the complex synapse. Direct continuity was found between the dense material of the spine apparatus and the punctum adhaerens. It is suggested, in accordance with other recent studies, that expansion of the synaptic active zone occurs by the addition and transformation of puncta adhaerentia. The spine apparatus may participate in this dynamic process as a possible donor of specific postsynaptic proteins.
从连续切片中重建了总共80个皮质轴突-棘突触连接，并在单张切片中分析了约100,000个。特别关注与穿孔、环状或马蹄形（=复杂）突触连接相关的黏着斑的出现，以及棘器的存在和位置关系。进一步的证据表明，棘器与简单（圆形或椭圆形）突触特化无关，但至少91%的复杂连接中存在棘器。棘器指向黏着斑，在至少71%的情况下，黏着斑似乎是复杂突触的一个组成部分。发现棘器的致密物质与黏着斑之间存在直接连续性。与其他近期研究一致，有人提出突触活性区的扩展是通过黏着斑的添加和转化实现的。棘器可能作为特定突触后蛋白的潜在供体参与这一动态过程。
