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微管、树突棘和棘器

Microtubules, dendritic spines and spine appratuses.

作者信息

Westrum L E, Jones D H, Gray E G, Barron J

出版信息

Cell Tissue Res. 1980;208(2):171-81. doi: 10.1007/BF00234868.

DOI:10.1007/BF00234868
PMID:6996822
Abstract

Using techniques for enhanced microtubular preservation, including albumin pretreatment (Gray, 1975), occipital cortex of rats was studied electron microscopically at various ages of development. A close structural relationship was seen between microtubules, sacs of SER and the postsynaptic "thickening" in primordial spines and with the dense "plate" material of spine apparatuses. Stereoscopic preparations in addition show a more complicated substructure than previously described for the "plate". Microtubules may contribute to the formation of the "plate" of the spine apparatus which in turn is associated with the postsynaptic "thickening" of the mature spine. Possible functional correlates are discussed.

摘要

运用包括白蛋白预处理(格雷,1975年)在内的增强微管保存技术,对不同发育阶段大鼠的枕叶皮质进行了电子显微镜研究。在原始棘突中的微管、滑面内质网囊泡与突触后“增厚”之间以及与棘器的致密“板”状物质之间,观察到了紧密的结构关系。立体标本还显示出比先前描述的“板”更为复杂的亚结构。微管可能有助于棘器“板”的形成,而棘器又与成熟棘突的突触后“增厚”相关。文中讨论了可能的功能关联。

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1
Microtubules, dendritic spines and spine appratuses.微管、树突棘和棘器
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2
Three-dimensional analysis of dendritic spines. II. Spine apparatus and other cytoplasmic components.
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3
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5
Morphological study of human epileptic dendrites.
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本文引用的文献

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微管作为神经网络形态和功能的调节剂:聚焦兴奋性、可塑性和记忆。
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Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory formation.在记忆形成过程中,树突棘中 eIF4E 的上调,而不是其他翻译起始因子。
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Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path.在麻醉兔的齿状区,刺激穿通通路后突触传递的长时程增强。
J Physiol. 1973 Jul;232(2):331-56. doi: 10.1113/jphysiol.1973.sp010273.
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Proteins of the postsynaptic density.突触后致密区的蛋白质
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Isolation of synaptic plasma membrane from brain by combined flotation-sedimentation density gradient centrifugation.通过联合浮选-沉降密度梯度离心法从大脑中分离突触质膜。
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An electron microscopic study of the normal synaptic relationships and early degenerative changes in the rat olfactory tubercle.大鼠嗅结节正常突触关系及早期退行性变化的电子显微镜研究。
Z Zellforsch Mikrosk Anat. 1972;127(4):462-82. doi: 10.1007/BF00306866.
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The "vesicle in a basket". A morphological study of the coated vesicle isolated from the nerve endings of the guinea pig brain, with special reference to the mechanism of membrane movements.“篮中囊泡”。对从豚鼠脑的神经末梢分离出的被膜囊泡的形态学研究,特别涉及膜运动机制。
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Microtubules and membrane specializations.微管与膜特化结构
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