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免疫抑制背景下的皮肤杆菌性血管瘤病:一名心脏移植受者的罕见病例。

Cutaneous bacillary angiomatosis in the setting of immunosuppression: A rare case in a heart transplant recipient.

作者信息

Devoy Chloe, Mydlarski Régine, Jafarian Fatemeh

机构信息

Cumming School of Medicine, University of Calgary, Alberta, Canada.

Division of Dermatology, Department of Medicine, Cumming School of Medicine, University of Calgary, AB, Canada.

出版信息

SAGE Open Med Case Rep. 2025 Jul 25;13:2050313X251358993. doi: 10.1177/2050313X251358993. eCollection 2025.

Abstract

Bacillary angiomatosis is a rare, opportunistic infection caused by . In the skin, neovascular proliferation results in erythematous and violaceous papules and nodules. While there are many reports of bacillary angiomatosis in solid organ transplant recipients, only two cases are documented in cardiac transplant recipients. Herein, we report a case of bacillary angiomatosis in a 67-year-old male post-orthotopic cardiac transplant who presented with erythematous papules scattered on the chest, back, and extremities. Biopsies revealed lobular capillary proliferation in the superficial dermis and positive Warthin-Starry staining. Nucleic acid amplification by PCR identified . After completing a 3-month course of doxycycline 100 mg twice daily, the patient had complete resolution of skin findings. The rise in solid organ transplants, combined with the expanding repertoire of immunosuppressive therapies, has significantly improved patient survival. However, it has also created a favorable environment for opportunistic infections, including bacillary angiomatosis, to emerge as a growing concern.

摘要

杆菌性血管瘤病是一种由……引起的罕见机会性感染。在皮肤中,新生血管增殖导致红斑和紫红色丘疹及结节。虽然实体器官移植受者中有许多杆菌性血管瘤病的报道,但心脏移植受者中仅有两例记录在案。在此,我们报告一例67岁男性原位心脏移植术后发生杆菌性血管瘤病的病例,该患者胸部、背部和四肢散在分布有红斑丘疹。活检显示真皮浅层小叶状毛细血管增生,Warthin-Starry染色阳性。通过聚合酶链反应(PCR)进行核酸扩增鉴定出……。在完成为期3个月、每日两次服用100毫克强力霉素的疗程后,患者皮肤症状完全消退。实体器官移植数量的增加,加上免疫抑制疗法种类的不断扩大,显著提高了患者的生存率。然而,这也为包括杆菌性血管瘤病在内的机会性感染创造了有利环境,使其成为一个日益受到关注的问题。

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Bacillary Angiomatosis in Renal Transplant Recipient: A Case Report.肾移植受者的杆菌性血管瘤病:一例报告
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