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与生命起源以及生长发育相关的儿科疾病中的氧化应激。

Oxidative stress in pediatric diseases associated with the origin of life and growth and development.

作者信息

Zheng Bo, Fu Jianhua

机构信息

Department of Pediatrics, Shenyang Women's and Children's Hospital, Shenyang, China.

Department of Pediatrics, Sheng Jing Hospital of China Medical University, Shenyang, China.

出版信息

Front Cell Dev Biol. 2025 Jul 15;13:1550765. doi: 10.3389/fcell.2025.1550765. eCollection 2025.

DOI:10.3389/fcell.2025.1550765
PMID:40735644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12303888/
Abstract

The presence of oxidative stress and an imbalance in antioxidant mechanisms have been demonstrated in numerous diseases. Furthermore, mounting evidence suggests that the occurrence, progression, and prognosis of certain pediatric diseases linked to the origin of life and growth and development are also associated with oxidative stress. In this review, we systematically analyze the relationship between oxidative stress and various pediatric diseases, proposing new theoretical foundations and therapeutic targets for their treatment.

摘要

氧化应激的存在以及抗氧化机制的失衡已在众多疾病中得到证实。此外，越来越多的证据表明，某些与生命起源以及生长发育相关的儿科疾病的发生、发展和预后也与氧化应激有关。在本综述中，我们系统地分析了氧化应激与各种儿科疾病之间的关系，为其治疗提出了新的理论基础和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/2aa4bfd5f75d/fcell-13-1550765-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/bfe94d30fa87/fcell-13-1550765-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/a34015dab5af/fcell-13-1550765-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/a3996db8caa4/fcell-13-1550765-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/2aa4bfd5f75d/fcell-13-1550765-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/bfe94d30fa87/fcell-13-1550765-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/a34015dab5af/fcell-13-1550765-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/a3996db8caa4/fcell-13-1550765-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cb/12303888/2aa4bfd5f75d/fcell-13-1550765-g004.jpg

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Adv Sci (Weinh). 2025 Feb;12(6):e2410953. doi: 10.1002/advs.202410953. Epub 2024 Dec 16.
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Higher oxidative balance score is linearly associated with reduced prevalence of chronic kidney disease in individuals with metabolic syndrome: evidence from NHANES 1999-2018.较高的氧化平衡评分与代谢综合征患者慢性肾脏病患病率降低呈线性相关：来自1999 - 2018年美国国家健康与营养检查调查（NHANES）的证据。
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Cellular and molecular biology of posttranslational modifications in cardiovascular disease.
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Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway.甲萘醌-4 通过 Sirt1-PGC-1α-TFAM 信号通路减少线粒体功能障碍缓解新生大鼠缺氧缺血性脑损伤。
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