非洲急性风湿热的患病率：系统评价与荟萃分析
The Prevalence Rates of Acute Rheumatic Fever in Africa: A Systematic Review and Meta-Analysis.
作者信息
Chinawa Josephat M, Chinawa Awoere T, Ogbuka Francis N, Elobuike Philip C, Nwankwo Ogonna
机构信息
University of Nigeria Ituku/Ozalla and University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Enugu State, Nigeria.
ESUCOM, Parklane Enugu, Enugu State, Nigeria.
出版信息
Sage Open Pediatr. 2025 Jul 28;12:30502225251357145. doi: 10.1177/30502225251357145. eCollection 2025 Jan-Dec.
BACKGROUND
Acute rheumatic fever (ARF) is an autoimmune disease that affects children.
OBJECTIVES
The meta-analysis aimed to establish pooled prevalence values and heterogeneity in the prevalence values.
METHODS
The study's published articles were searched using PubMed, the Cochrane Database of Systematic Reviews, Google Scholar, and the Institute for Scientific Information (ISI) Web of Science.
RESULTS
The pooled total sample size was 386, 875 and the mean (SD) of the pooled sample size was 15 475 ± 24 765.988 at 95% intervals. The analysis revealed an estimated overall prevalence of acute rheumatic fever (ARF) in Africa of 1% under both the common and random effects models. The between-study variance (τ²) was 2.5043, and the ² statistics- representing the percentage of total variability attributable to heterogeneity was extremely high at 98.2%.
CONCLUSION
There is a clear statistical difference in prevalence rates and a high degree of heterogeneity in individual studies.
背景
急性风湿热（ARF）是一种影响儿童的自身免疫性疾病。
目的
本荟萃分析旨在确定合并患病率值以及患病率值的异质性。
方法
使用PubMed、Cochrane系统评价数据库、谷歌学术和科学信息研究所（ISI）科学网检索该研究的已发表文章。
结果
合并总样本量为386,875，合并样本量的均值（标准差）在95%区间为15475±24765.988。分析显示，在固定效应模型和随机效应模型下，非洲急性风湿热（ARF）的估计总体患病率均为1%。研究间方差（τ²）为2.5043，代表异质性所致总变异性百分比的I²统计量极高，为98.2%。
结论
患病率存在明显的统计学差异，且各研究存在高度异质性。
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