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Investigation of long-term epigenetic changes in the Nr3c1 gene by neonatal valproate exposure in juvenile rats.

作者信息

Jang Eun Hye, Kim Soon Ae

机构信息

Department of Pharmacology, School of Medicine, Eulji University, Daejeon 34824, Republic of Korea.

出版信息

Genes Dis. 2025 Mar 8;12(6):101588. doi: 10.1016/j.gendis.2025.101588. eCollection 2025 Nov.

DOI:10.1016/j.gendis.2025.101588
PMID:40735696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12305572/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23a/12305572/ff19c0f5af25/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23a/12305572/91b1e5c4710c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23a/12305572/9d88d76dd6cc/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23a/12305572/ff19c0f5af25/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23a/12305572/91b1e5c4710c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23a/12305572/9d88d76dd6cc/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b23a/12305572/ff19c0f5af25/figs2.jpg

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本文引用的文献

1
Long-Term Epigenetic Regulation of Expression in Neonatal Valproate-Exposed Rat Hippocampus with Sex-Related Differences.长期的表观遗传调控与性别相关差异：新生期暴露于丙戊酸的大鼠海马中的表达。
Int J Mol Sci. 2024 May 13;25(10):5287. doi: 10.3390/ijms25105287.
2
Neonatal Exposure to Valproate Induces Long-Term Alterations in Steroid Hormone Levels in the Brain Cortex of Prepubertal Rats.新生期接触丙戊酸会导致未成年大鼠大脑皮质中类固醇激素水平的长期改变。
Int J Mol Sci. 2023 Apr 3;24(7):6681. doi: 10.3390/ijms24076681.
3
A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism.
丙戊酸致自闭症模型啮齿动物的系统评价
Dev Neurosci. 2020;42(1):12-48. doi: 10.1159/000509109. Epub 2020 Aug 18.
4
Valproic acid stimulates proliferation of glial precursors during cortical gliogenesis in developing rat.丙戊酸在发育中大鼠的皮质神经胶质生成过程中刺激神经胶质前体细胞的增殖。
Dev Neurobiol. 2016 Jul;76(7):780-98. doi: 10.1002/dneu.22359. Epub 2015 Nov 17.
5
Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome.在胎儿丙戊酸盐综合征斑马鱼模型中，丙戊酸使ascl1b/Ascl1沉默导致5-羟色胺能分化失败。
Dis Model Mech. 2014 Jan;7(1):107-17. doi: 10.1242/dmm.013219. Epub 2013 Oct 17.