Hussein S, Alblooshi N, Kandakurti P, Osman H, Mostafa A, Abdelfatah M, Alsubhi A, Algarni A, Ali E, Dawod O, Abdalhabib E, Babiker R, Abdelhadi M, Alfeel A
1Medical Laboratory Sciences Department, College of Health Sciences, Gulf Medical University, Ajman, UAE.
2Faculty of Medical and Health Sciences, Liwa University, Abu Dhabi, UAE.
Georgian Med News. 2025 May(362):209-213.
The relationship between thyroid hormones and glucose metabolism is complex. Thyroid hormones, particularly triiodothyronine (FT3) and thyroxine (FT4), play crucial roles in regulating basal metabolic rate, lipid metabolism, and glucose homeostasis. Alterations in these hormones can influence insulin sensitivity and secretion. This study aims to evaluate serum TSH, FT3, FT4, and fasting blood glucose levels to demonstrate the association between thyroid dysfunction and T2DM.
This study included 219 male and female participants aged 23 to 74 years; 149 patient participants diagnosed with T2DM using the American Diabetes Association's (ADA) criteria compared with 70 non-diabetic patients. Thyroid function tests, including serum Thyroid Stimulating Hormone (TSH), Free Triiodothyronine (FT3), and Free Thyroxine (FT4) levels, were performed. The patients divided into three age groups based on WHO age group classification: Young Adults (23-30), Middle-aged adults (31-45) and Old-aged adults (>45). Statistical analysis by SPSS 26 used to determine the relationship between fasting blood glucose and thyroid hormone levels.
This study conducted on 219 diabetic and non- diabetic patient males and females 149 males and females' diabetics compared with 70 males and females with non- diabetes mullites disease, age of two groups between 23- 74 years and classified into three groups young adults, middle-aged adults, and old-aged adults. Observed from these results significant difference in the mean levels of FBG in the diabetic patients (116.4±21.1 mg/dL) compared to non-diabetic individuals (96.7±14.1 mg/dL) with a P value=0.031. TSH levels were significantly lower in diabetic patients (2.18±0.97 µIU/mL) than in non-diabetics (3.05±1.09 µIU/mL; P value=0.029). The results showed significant elevated of FT3 levels in diabetic patients (1.81±0.52 pg/mL) compared to non-diabetic's individuals (1.35±0.25 pg/mL; P value=0.048). Also, FT4 levels significantly higher in the diabetic patients (114±17.7 ng/L) compared to the non-diabetic individuals (107±18.4 ng/L; P value=0.018). These results demonstrated that diabetes mellitus play important role associated with changed in both glucose metabolism and thyroid hormone profiles.
Significant differences in fasting blood glucose and thyroid hormone levels between the diabetic and non-diabetic patients were observed in this study. The correlation between diabetes, thyroid and glucose metabolism was demonstrated by a negative correlation with TSH and positive correlations with FT3, FT4, and glucose.
甲状腺激素与葡萄糖代谢之间的关系较为复杂。甲状腺激素，尤其是三碘甲状腺原氨酸（FT3）和甲状腺素（FT4），在调节基础代谢率、脂质代谢和葡萄糖稳态方面发挥着关键作用。这些激素的改变会影响胰岛素敏感性和分泌。本研究旨在评估血清促甲状腺激素（TSH）、FT3、FT4和空腹血糖水平，以证明甲状腺功能障碍与2型糖尿病（T2DM）之间的关联。
本研究纳入了219名年龄在23至74岁之间的男性和女性参与者；其中149名患者参与者根据美国糖尿病协会（ADA）的标准被诊断为T2DM，与70名非糖尿病患者进行比较。进行了甲状腺功能测试，包括血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）水平。根据世界卫生组织的年龄组分类，将患者分为三个年龄组：青年成年人（23 - 30岁）、中年成年人（31 - 45岁）和老年成年人（>45岁）。使用SPSS 26进行统计分析，以确定空腹血糖与甲状腺激素水平之间的关系。
本研究对219名糖尿病和非糖尿病患者男性和女性进行了研究，149名男性和女性糖尿病患者与70名男性和女性非糖尿病患者进行比较，两组年龄在23 - 74岁之间，并分为青年成年人、中年成年人和老年成年人三组。从这些结果中观察到，糖尿病患者的空腹血糖平均水平（116.4±21.1 mg/dL）与非糖尿病个体（96.7±14.1 mg/dL）相比存在显著差异，P值 = 0.031。糖尿病患者的TSH水平（2.18±0.97 µIU/mL）显著低于非糖尿病患者（3.05±1.09 µIU/mL；P值 = 0.029）。结果显示，糖尿病患者的FT3水平（1.81±0.52 pg/mL）与非糖尿病个体（1.35±0.25 pg/mL；P值 = 0.048）相比显著升高。此外，糖尿病患者的FT4水平（114±17.7 ng/L）显著高于非糖尿病个体（107±18.4 ng/L；P值 = 0.018）。这些结果表明，糖尿病在葡萄糖代谢和甲状腺激素谱的变化中起着重要作用。
本研究观察到糖尿病患者与非糖尿病患者在空腹血糖和甲状腺激素水平上存在显著差异。糖尿病、甲状腺与葡萄糖代谢之间的相关性通过与TSH的负相关以及与FT3、FT4和葡萄糖的正相关得以证明。
