Syvälahti E, Hyyppä M T, Salminen J K
Ann Clin Res. 1985;17(4):148-51.
Non-suppression of the hypothalamic-pituitary-adrenocortical activity on the dexamethasone suppression test was found in 27/115 patients who were referred to consulting psychiatrists in the Psychiatric Outpatient Clinic of Turku University Central Hospital and in the Rehabilitation Research Centre because of unspecific chronic pain complaints. Depressive symptoms in the patients were identified by the Research Diagnostic Criteria for definite or probable endogenous and non-endogenous depressive disorders. The cortisol levels after dexamethasone suppression were significantly higher in endogenous than in non-endogenous patients and it uncovered masked depression in some complex patients. However, nonsuppression in the dexamethasone suppression test was not specifically associated with the pain-prone disorder, which was further characterized by the factor models of the Hamilton Depression Scale.
在图尔库大学中心医院精神科门诊和康复研究中心，因非特异性慢性疼痛主诉而转诊至精神科会诊的115例患者中，有27例在地塞米松抑制试验中下丘脑-垂体-肾上腺皮质活动未被抑制。通过研究诊断标准确定患者是否患有明确或可能的内源性和非内源性抑郁障碍，以此识别患者的抑郁症状。地塞米松抑制后，内源性患者的皮质醇水平显著高于非内源性患者，并且该试验揭示了一些复杂患者中被掩盖的抑郁。然而，地塞米松抑制试验中的未被抑制现象与疼痛易发性障碍并无特异性关联，后者通过汉密尔顿抑郁量表的因子模型进一步表征。
