Helme R D, McKernan S
Ann Neurol. 1985 Oct;18(4):505-9. doi: 10.1002/ana.410180414.
The flare response to noxious stimulation of the skin is mediated by polymodal nociceptors of C fiber primary afferent nerves. Topical application of capsaicin initiates a flare response and burning pain. In this study, the variability of capsaicin-induced flare and pain was assessed in 220 subjects. The major factors in flare response are body site and age; more severe reactions occur in more proximal sites and in younger subjects. Larger flares were shown to be associated with greater pain. Variability is probably due to differences in the structure and reactivity of the neurovascular unit as proposed in the Lewis model of the axon reflex. It may prove possible to assess polymodal nociceptor function using topical capsaicin in disease states that affect the peripheral terminals of primary afferent nerves.
皮肤对伤害性刺激的潮红反应由C纤维初级传入神经的多模式伤害感受器介导。局部应用辣椒素可引发潮红反应和灼痛。在本研究中，对220名受试者评估了辣椒素诱导的潮红和疼痛的变异性。潮红反应的主要因素是身体部位和年龄；更严重的反应发生在更靠近身体近端的部位和更年轻的受试者中。更大的潮红与更剧烈的疼痛相关。变异性可能是由于轴突反射的刘易斯模型中提出的神经血管单元的结构和反应性差异所致。在影响初级传入神经外周终末的疾病状态下，使用局部辣椒素评估多模式伤害感受器功能可能是可行的。
