Wu Dengxian, Fu Kai, Jiang Gongan, Qiao Liang, Yao Yao, Chen Dongyang, Jiang Qing
Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu, 210008, PR China.
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, PR China.
BMC Musculoskelet Disord. 2025 Jul 30;26(1):733. doi: 10.1186/s12891-025-08969-2.
Venous thromboembolism (VTE) is a significant complication following total knee arthroplasty (TKA), with considerable implications for patient outcomes. The purpose of this study is to assess the incidence of VTE after fast-track TKA at our center and to evaluate whether the use of graded compression stockings (GCS) can further reduce VTE incidence within this regimen.
A total of 660 patients undergoing primary TKA between January 1, 2018, and December 31, 2022, were included. Patients were categorized into two groups: GCS group (n = 390) and non-GCS group (n = 270). Knee-length GCS were applied to patients in the GCS group. Diagnosis of deep vein thrombosis (DVT) was confirmed by bilateral lower extremity duplex venous ultrasonography. Incidence and locations of thrombosis were recorded. Demographic characteristics, laboratory indices, and surgical variables were collected. Univariate and multivariate regression analyses were performed to identify risk factors for thrombosis.
The overall incidence of VTE after fast-track TKA was 6.2% (41/660), with no cases of proximal DVT or pulmonary embolism (PE). The incidence of DVT was significantly lower in the GCS group compared to the non-GCS group (3.8% vs. 9.6%). After adjusting for confounders, multivariate analysis demonstrated that absence of GCS, older age, and history of cardiovascular disease were independent risk factors for postoperative DVT.
In conclusion, this study found a low incidence of VTE after fast-track TKA, and the use of GCS may further reduce the occurrence of early postoperative calf muscular vein thrombosis (CMVT) when combined with anticoagulants plus intermittent pneumatic compression (IPC).
静脉血栓栓塞症(VTE)是全膝关节置换术(TKA)后的一种严重并发症,对患者的预后有重大影响。本研究的目的是评估我院中心快速康复全膝关节置换术后VTE的发生率,并评估使用分级压力弹力袜(GCS)是否能在该方案中进一步降低VTE的发生率。
纳入2018年1月1日至2022年12月31日期间接受初次全膝关节置换术的660例患者。患者分为两组:GCS组(n = 390)和非GCS组(n = 270)。GCS组患者使用膝长型GCS。通过双侧下肢静脉超声检查确诊深静脉血栓形成(DVT)。记录血栓形成的发生率和部位。收集人口统计学特征、实验室指标和手术变量。进行单因素和多因素回归分析以确定血栓形成的危险因素。
快速康复全膝关节置换术后VTE的总体发生率为6.2%(41/660),无近端DVT或肺栓塞(PE)病例。GCS组DVT的发生率明显低于非GCS组(3.8%对9.6%)。在调整混杂因素后,多因素分析表明未使用GCS、年龄较大和有心血管疾病史是术后DVT的独立危险因素。
总之,本研究发现快速康复全膝关节置换术后VTE的发生率较低,并且当与抗凝剂加间歇性气动压迫(IPC)联合使用时,GCS的使用可能会进一步降低术后早期小腿肌肉静脉血栓形成(CMVT)的发生率。