Rose Deborah K, Pfund Gabrielle, Lee Jillian K, Liu Andy J, Benitez Andreana, Fani Negar, Walker Keenan A, Mielke Michelle M, Bateman James R
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Human Development & Family Science, Auburn University, Auburn, Alabama, USA.
Alzheimers Dement. 2025 Aug;21(8):e70523. doi: 10.1002/alz.70523.
Adverse childhood experiences (ACEs) disrupt brain development and increase vulnerability to Alzheimer's disease and related dementias (ADRD). We explored how ACEs impact neuroimaging, plasma biomarkers, and cognition in older adults.
Data from 214 participants aged ≥ 55 years were analyzed using linear and logistic regression, adjusting for demographic covariates.
Financial need associated negatively with Montreal Cognitive Assessment scores (β = -0.10, p = 0.011). Lower mean diffusivity across white matter tracts associated with parental violence (β = -0.01, p = 0.03). Lower glial fibrillary acidic protein associated with parental intimidation (β = -0.07, p = 0.01) and parental violence (β = -0.18, p = 0.006). Family problems and separation (β = -0.16, p = 0.003), financial need (β = -0.1, p = 0.04), and parental intimidation (β = -0.05, p = 0.01) inversely associated with neurofilament light chain.
Findings challenge the notion that ACEs uniformly accelerate neurodegeneration. Longitudinal studies are needed to determine whether these results reflect resilience, survivorship, or cohort-specific factors influencing ADRD risk.
Adverse childhood experiences (ACEs) may elicit compensatory neural responses in aging. Financial need was associated with lower global cognition (Montreal Cognitive Assessment scores). Some ACEs (e.g., financial need, parental intimidation) linked to lower plasma neurofilament light chain. Parental violence linked to lower glial fibrillary acidic protein and mean diffusivity values, implying intact white mattery integrity.
童年不良经历（ACEs）会扰乱大脑发育，并增加患阿尔茨海默病及相关痴呆症（ADRD）的易感性。我们探讨了ACEs如何影响老年人的神经影像学、血浆生物标志物和认知。
对214名年龄≥55岁参与者的数据进行线性和逻辑回归分析，并对人口统计学协变量进行校正。
经济需求与蒙特利尔认知评估得分呈负相关（β = -0.10，p = 0.011）。与父母暴力相关的白质束平均扩散率较低（β = -0.01，p = 0.03）。与父母恐吓（β = -0.07，p = 0.01）和父母暴力（β = -0.18，p = 0.006）相关的胶质纤维酸性蛋白较低。家庭问题与分离（β = -0.16，p = 0.003）、经济需求（β = -0.1，p = 0.04）以及父母恐吓（β = -0.05，p = 0.01）与神经丝轻链呈负相关。
研究结果挑战了ACEs会一致加速神经退行性变的观点。需要进行纵向研究以确定这些结果是否反映了恢复力、生存能力或影响ADRD风险的特定队列因素。
童年不良经历（ACEs）可能会在衰老过程中引发代偿性神经反应。经济需求与较低的整体认知（蒙特利尔认知评估得分）相关。一些ACEs（如经济需求、父母恐吓）与较低的血浆神经丝轻链相关。父母暴力与较低的胶质纤维酸性蛋白和平均扩散率值相关，这意味着白质完整性完好。
