Qi Wanling, Wang Ruie, Khasawneh Saleh Mahmoud Saleh, Hui Fangyuan, Liu Yan
Department of Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
J Dermatolog Treat. 2025 Dec;36(1):2540594. doi: 10.1080/09546634.2025.2540594. Epub 2025 Jul 31.
Acne vulgaris is a chronic inflammatory skin disease, and the inflammatory cytokines play a significant role in its pathophysiology. At present, oral isotretinoin is considered as the most effective treatment for acne. However, its specific anti-inflammatory mechanisms are only partially understood.
The research included 75 patients with acne severity levels II, III and IV together with 25 healthy participants in this prospective controlled clinical trial. Patients received 20 mg/day oral isotretinoin for eight weeks. The research team evaluated inflammatory cytokine levels (IL-8, IL-36, TNF-α, TSLP, and TWEAK) at the beginning and end of the study.
The levels of IL-8, IL-36, TNF-α, TSLP, and TWEAK were found to be significantly higher in acne patients as compared to controls ( < 0.05). IL-8, IL-36, and TWEAK levels were found to be significantly decreased after 8 weeks of isotretinoin treatment ( < 0.05). There was no correlation found between the severity of acne and inflammatory cytokine levels ( > 0.05).
The anti-inflammatory effects of isotretinoin in acne patients result from its ability to decrease serum levels of inflammatory cytokines (IL-8, IL-36, TNF-α, TSLP, and TWEAK).
寻常痤疮是一种慢性炎症性皮肤病，炎症细胞因子在其病理生理学中起重要作用。目前，口服异维A酸被认为是治疗痤疮最有效的方法。然而，其具体的抗炎机制仅得到部分了解。
在这项前瞻性对照临床试验中，研究纳入了75例II级、III级和IV级痤疮患者以及25名健康参与者。患者接受每日20毫克口服异维A酸治疗，为期八周。研究团队在研究开始和结束时评估炎症细胞因子水平（IL-8、IL-36、TNF-α、TSLP和TWEAK）。
与对照组相比，痤疮患者的IL-8、IL-36、TNF-α、TSLP和TWEAK水平显著更高（<0.05）。异维A酸治疗8周后，IL-8、IL-36和TWEAK水平显著降低（<0.05）。痤疮严重程度与炎症细胞因子水平之间未发现相关性（>0.05）。
异维A酸对痤疮患者的抗炎作用源于其降低血清炎症细胞因子（IL-8、IL-36、TNF-α、TSLP和TWEAK）水平的能力。
