Sood Ankita, Patwardhan Vaidehi, Nayak Sudipta, Chintalapani Srinidhi, Mandal Sachin, Tikoo Kulbhushan
Laboratory of Epigenetics and Diseases, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, India.
Nanomedicine (Lond). 2025 Aug;20(16):2061-2092. doi: 10.1080/17435889.2025.2535277. Epub 2025 Jul 31.
The convergence of nanoscale engineering and biomimetics is revolutionizing wound care by enabling the development of bioengineered nanoparticles with exceptional therapeutic precision. This review synthesizes recent advances in nanoparticle-based interventions that mimic biological systems for targeted, controlled, and stage-specific wound healing. Innovations covered include receptor-specific ligand conjugation, bioactive scaffolds, nucleic acid-based systems, microenvironment-responsive nanomaterials, stimuli-activated metal nanoparticles, biosensing platforms, and exosome-mimicking systems. These approaches offer enhanced modulation of the wound microenvironment and promote tissue regeneration, addressing major drawbacks of conventional therapies. Therapeutic efficacy is critically evaluated using data from recent in vitro and in vivo studies. A structured literature search was conducted using PubMed, Scopus, Web of Science, and ScienceDirect, covering publications from January 2015 to June 2025. Relevant studies were selected based on their focus on nanoparticle-based wound-healing strategies, bioengineering innovations, and translational potential. The review also discusses challenges such as biocompatibility, biodistribution, manufacturing scalability, and regulatory hurdles that limit clinical adoption. Finally, this review explores the future paradigm of personalized nanotherapeutics, tailored to individual patient pathophysiology. By summarizing current developments and forecasting future directions, this review highlights the transformative role of bioengineered nanoparticles in next-generation wound healing and regenerative medicine.
纳米尺度工程与仿生学的融合正在彻底改变伤口护理领域，它使得具有卓越治疗精准度的生物工程纳米颗粒得以开发。本综述综合了基于纳米颗粒的干预措施的最新进展，这些措施模仿生物系统以实现靶向、可控和阶段特异性的伤口愈合。涵盖的创新包括受体特异性配体偶联、生物活性支架、基于核酸的系统、微环境响应性纳米材料、刺激激活金属纳米颗粒、生物传感平台和外泌体模拟系统。这些方法能够增强对伤口微环境的调节并促进组织再生，解决了传统疗法的主要缺点。利用近期体外和体内研究的数据对治疗效果进行了严格评估。使用PubMed、Scopus、Web of Science和ScienceDirect进行了结构化文献检索，涵盖2015年1月至2025年6月的出版物。根据其对基于纳米颗粒的伤口愈合策略、生物工程创新和转化潜力的关注来选择相关研究。该综述还讨论了限制临床应用的挑战，如生物相容性、生物分布、制造可扩展性和监管障碍。最后，本综述探讨了针对个体患者病理生理学的个性化纳米治疗的未来模式。通过总结当前的发展并预测未来方向，本综述突出了生物工程纳米颗粒在下一代伤口愈合和再生医学中的变革性作用。
