Anaissie E, Tohmé J F
Arch Intern Med. 1985 Dec;145(12):2248-9.
beta-Adrenergic blockers are considered the drugs of choice in the management of the hyperadrenergic state in hyperthyroidism. However, we observed a patient in thyroid storm and coma who failed to respond to large doses of oral and intravenous propranolol hydrochloride but who responded promptly to intramuscular reserpine. Reserpine may have been lifesaving and should be considered in propranolol-resistant hyperthyroidism and in hyperthyroid patients in whom propranolol is contraindicated.
β-肾上腺素能阻滞剂被认为是治疗甲状腺功能亢进高肾上腺素能状态的首选药物。然而，我们观察到一名处于甲状腺危象和昏迷状态的患者，对大剂量口服和静脉注射盐酸普萘洛尔无反应，但对肌肉注射利血平迅速产生反应。利血平可能挽救了患者生命，对于普萘洛尔耐药的甲状腺功能亢进症以及普萘洛尔禁忌的甲状腺功能亢进患者，应考虑使用利血平。
