维生素E和C补充剂联合使用对血浆氧化应激生物标志物和抗氧化能力的影响：一项采用GRADE评估的随机对照试验系统评价和Meta分析以及Meta回归分析
The effect of co-administration of vitamin E and C supplements on plasma oxidative stress biomarkers and antioxidant capacity: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials with meta-regression.
作者信息
Moabedi Mahdi, Milajerdi Alireza
机构信息
Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Front Immunol. 2025 Jul 16;16:1547888. doi: 10.3389/fimmu.2025.1547888. eCollection 2025.
BACKGROUND
There is no conclusion on the effect of vitamins E and C on plasma biomarkers of oxidative stress and antioxidant status. We conducted this meta-analysis to gain a clearer view of this area.
METHODS
We performed a systematic search in online databases using the relevant keyword combination. Randomized controlled trials that investigated the effect of vitamins E and C simultaneously, compared with control, on oxidative stress and antioxidant status biomarkers were included in the analyses.
RESULTS
A total of 17 trials were included in the meta-analysis, building a total sample size of 965. The dosage of vitamin E and C supplements varied from 54 to 536 and 250 to 1000 mg/d, respectively, across included studies. We found significant results for MDA [WMD: -0.38, 95% CI: -0.48, -0.28 µg/L, P <0.001], LP [WMD: -1.01, 95% CI: -1.49, -0.54 µg/L, P <0.001], TAC [WMD: 0.09, 95% CI: 0.05, 0.13 mmol/L, P <0.001], and GPx [WMD: 1251.74, 95% CI: 258.92, 2244.56 U/L, P = 0.013], but not for SOD [WMD: 16.69, 95% CI: -29.40, 62.78 U/L, P = 0.278]. Regarding subgroup analysis, only studies on unhealthy participants showed a significant effect on MDA [WMD: -1.62, 95% CI: -2.08, -1.15 µg/L, P <0.001] and TAC [WMD: 0.08, 95% CI: 0.03, 0.14 mmol/L, P <0.001], unlike LP, where significance was only observed in healthy adults [WMD: -0.41, 95% CI: -0.45, -0.37 µg/L, P <0.001]. Moreover, only studies in which a placebo was administered, supplementation of vitamins showed significant effects on MDA [WMD: -0.47, 95% CI: -0.58, -0.35 µg/L, P <0.001], LP [WMD: -1.28, 95% CI: -1.85, -0.72 µg/L, P <0.001], and TAC [WMD: 0.10, 95% CI: 0.05, 0.15 mmol/L, P <0.001].
CONCLUSION
Our review and analyses revealed that a combination of vitamin C and E has a beneficial effect on oxidative stress biomarkers and antioxidant status.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024590197, identifier CRD42024590197.
背景
维生素E和C对氧化应激和抗氧化状态的血浆生物标志物的影响尚无定论。我们进行了这项荟萃分析，以更清楚地了解该领域。
方法
我们使用相关关键词组合在在线数据库中进行了系统检索。分析纳入了将维生素E和C同时使用与对照组相比，对氧化应激和抗氧化状态生物标志物影响的随机对照试验。
结果
荟萃分析共纳入17项试验，总样本量为965。纳入研究中，维生素E和C补充剂的剂量分别从54至536毫克/天和250至1000毫克/天不等。我们发现丙二醛（MDA）[加权均数差（WMD）：-0.38，95%置信区间（CI）：-0.48，-0.28微克/升，P<0.001]、脂质过氧化物（LP）[WMD：-1.01，95%CI：-1.49，-0.54微克/升，P<0.001]、总抗氧化能力（TAC）[WMD：0.09，95%CI：0.05，0.13毫摩尔/升，P<0.001]和谷胱甘肽过氧化物酶（GPx）[WMD：1251.74，95%CI：258.92，2244.56单位/升，P=0.013]有显著结果，但超氧化物歧化酶（SOD）无显著结果[WMD：16.69，95%CI：-29.40，62.78单位/升，P=0.278]。关于亚组分析，仅针对不健康参与者的研究显示对MDA[WMD：-1.62，95%CI：-2.08，-1.15微克/升，P<0.001]和TAC[WMD：0.08，95%CI：0.03，0.14毫摩尔/升，P<0.001]有显著影响，与LP不同，LP仅在健康成年人中观察到显著差异[WMD：-0.41，95%CI：-0.45，-0.37微克/升，P<0.001]。此外，仅在给予安慰剂的研究中，维生素补充剂对MDA[WMD：-0.47，95%CI：-0.58，-
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