预测直肠癌新辅助放化疗反应：从生物标志物到临床实践的见解
Predicting neoadjuvant chemoradiotherapy response in rectal cancer: Insights from biomarkers to clinical practice.
作者信息
Pehlevan-Özel Hikmet, Şahingöz Eda, Altaş Mert, Tez Mesut
机构信息
Department of Surgery, Ankara City Hospital, Ankara 06800, Türkiye.
Department of General Surgery, University of Health Sciences, Ankara 06100, Türkiye.
出版信息
World J Gastrointest Surg. 2025 Jul 27;17(7):106724. doi: 10.4240/wjgs.v17.i7.106724.
Abstract
Rectal cancer poses a major global health challenge, with neoadjuvant chemoradiotherapy improving outcomes in locally advanced cases by reducing tumor burden and recurrence risk. However, response variability, including only 15%-20% of patients achieving pathological complete response, underscores the urgent need for accurate predictive tools. This review explored current and emerging biomarkers to enhance neoadjuvant chemoradiotherapy response prediction and inform clinical practice.
摘要
直肠癌是一项重大的全球健康挑战，新辅助放化疗通过减轻肿瘤负担和降低复发风险改善局部晚期病例的治疗效果。然而，反应变异性，包括仅有15%-20%的患者实现病理完全缓解，凸显了对准确预测工具的迫切需求。本综述探讨了当前和新出现的生物标志物，以加强新辅助放化疗反应预测并为临床实践提供依据。
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本文引用的文献
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