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两种远缘线虫物种的比较连接组学揭示了神经系统进化模式。

Comparative connectomics of two distantly related nematode species reveals patterns of nervous system evolution.

作者信息

Cook Steven J, Kalinski Cristine A, Loer Curtis M, Memar Nadin, Majeed Maryam, Stephen Sarah Rebecca, Bumbarger Daniel J, Riebesell Metta, Conradt Barbara, Schnabel Ralf, Sommer Ralf J, Hobert Oliver

机构信息

Department of Biological Sciences, Columbia University; Howard Hughes Medical Institute, New York, NY, USA.

Department of Biology, University of San Diego, San Diego, CA, USA.

出版信息

Science. 2025 Jul 31;389(6759):eadx2143. doi: 10.1126/science.adx2143.

DOI:10.1126/science.adx2143
PMID:40743352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12330220/
Abstract

Understanding the evolution of the bilaterian brain requires a detailed exploration of the precise nature of cellular and subcellular differences between related species. We undertook an electron micrographic reconstruction of the brain of the predatory nematode and compared the results with the brain of , which diverged at least 100 million years ago. We revealed changes in neuronal cell death, neuronal cell position, axodendritic projection patterns, and synaptic connectivity of homologous neurons that display no obvious changes in overall neurite morphology and projection patterns. These multiscale patterns of evolutionary changes show no bias to specific brain regions or neuron types.

摘要

要了解两侧对称动物大脑的进化，需要详细探究相关物种之间细胞和亚细胞差异的确切性质。我们对捕食性线虫的大脑进行了电子显微镜重建，并将结果与至少在1亿年前就已分化的[未提及的物种名称]的大脑进行了比较。我们揭示了同源神经元在神经元细胞死亡、神经元细胞位置、轴突树突投射模式和突触连接方面的变化，而这些同源神经元在整体神经突形态和投射模式上没有明显变化。这些多尺度的进化变化模式对特定脑区或神经元类型没有偏向性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/9516eaa3e4bc/nihms-2101571-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/92662df4c31f/nihms-2101571-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/66b13856e7ad/nihms-2101571-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/1709b185a3f5/nihms-2101571-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/aa90f774398a/nihms-2101571-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/9516eaa3e4bc/nihms-2101571-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/92662df4c31f/nihms-2101571-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/22eb6973bd7d/nihms-2101571-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/c35feb77cc7d/nihms-2101571-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/66b13856e7ad/nihms-2101571-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/1709b185a3f5/nihms-2101571-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/aa90f774398a/nihms-2101571-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4af/12330220/9516eaa3e4bc/nihms-2101571-f0007.jpg

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Curr Biol. 2023 Jun 5;33(11):2315-2320.e2. doi: 10.1016/j.cub.2023.04.071. Epub 2023 May 26.
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Evolution of central neural circuits: state of the art and perspectives.中枢神经回路的演化：最新进展与展望。
Nat Rev Neurosci. 2022 Dec;23(12):725-743. doi: 10.1038/s41583-022-00644-y. Epub 2022 Oct 26.
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The bHLH-PAS gene is expressed in the AVH, not AVJ interneurons.bHLH-PAS基因在AVH中表达，而非在AVJ中间神经元中表达。
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Connectomes across development reveal principles of brain maturation.连接组学揭示大脑发育的成熟规律。
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The Prop1-like homeobox gene specifies the identity of synaptically connected neurons.类 Prop1 同源盒基因 决定了突触连接神经元的身份。
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