Wang Shuyue, Yu Lei, Fang Jichen, Jiang Yu
Department of Anesthesiology, the Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, 161000, Heilongjiang, China.
The Second Affiliated Hospital of Qiqihar Medical College, No. 37 Zhonghua West Road, Jianhua District, Qiqihar, 161000, Heilongjiang, China.
BMC Urol. 2025 Jul 31;25(1):186. doi: 10.1186/s12894-025-01880-x.
To investigate the effects of different doses of ephedrine spinal anesthesia on hemodynamics and adverse reactions in patients undergoing transurethral resection of the prostate (TURP).
Sixty patients who underwent TURP in our hospital from October 2023 to December 2024 were retrospectively selected as the research subjects. According to the different doses of ephedrine needed during the operation, the patients were divided into observation group (10 mg ephedrine, n = 30) and control group (5 mg ephedrine, n = 30). The anesthetic effect of the two groups was evaluated. The changes of hemodynamics and stress indicators of the two groups were detected and the incidence of adverse reactions was analyzed.
Compared with the control group, the onset time of motor block and sensory block in the observation group was significantly shorter (P < 0.05), but the duration of motor block and sensory block was significantly longer (P < 0.05). The heart rate of the observation group was lower than that of the control group 10 min of administration and at the beginning of resection (P < 0.05). The diastolic blood pressure and systolic blood pressure in the observation group were higher than the control group (P < 0.05). The levels of cortisol (COR) and epinephrine (EPI) in the observation group were lower than the control group (P < 0.05). The incidence of adverse reactions in the control group was 53.33% (16/30), which was higher than 20.00% (6/30) in the observation group (P < 0.05).
The application of 10 mg ephedrine in TURP can help stabilize the hemodynamics of patients, reduce the stress response of the body, and decrease the incidence of hypotension and other adverse reactions.
探讨不同剂量麻黄碱腰麻对经尿道前列腺电切术（TURP）患者血流动力学及不良反应的影响。
回顾性选取2023年10月至2024年12月在我院行TURP的60例患者作为研究对象。根据术中所需麻黄碱剂量不同，将患者分为观察组（麻黄碱10mg，n = 30）和对照组（麻黄碱5mg，n = 30）。评估两组麻醉效果。检测两组血流动力学及应激指标变化并分析不良反应发生率。
与对照组相比，观察组运动阻滞和感觉阻滞起效时间明显缩短（P < 0.05），但运动阻滞和感觉阻滞持续时间明显延长（P < 0.05）。给药10分钟及切除开始时，观察组心率低于对照组（P < 0.05）。观察组舒张压和收缩压高于对照组（P < 0.05）。观察组皮质醇（COR）和肾上腺素（EPI）水平低于对照组（P < 0.05）。对照组不良反应发生率为53.33%（16/30），高于观察组的20.00%（6/30）（P < 0.05）。
10mg麻黄碱应用于TURP可有助于稳定患者血流动力学，减轻机体应激反应，降低低血压等不良反应发生率。
