Özmen Murat, Altınkaya Onur, Saraç İbrahim, Aydemir Selim, Aydın Sidar Şiyar, Aydınyılmaz Faruk, Aksakal Emrah
Department of Cardiology, University of Health Sciences, Erzurum Bolge Training and Research Hospital, Yakutiye/Erzurum, 25240, Turkey.
Department of Cardiology, Ataturk University, Erzurum, Turkey.
BMC Cardiovasc Disord. 2025 Jul 31;25(1):559. doi: 10.1186/s12872-025-05053-4.
The systemic immune-inflammation index (SII), a novel marker derived from the combination of platelet, neutrophil, and lymphocyte counts, has been linked to unfavorable clinical outcomes in various malignancies and inflammatory conditions. This study aims to assess the association between SII and disease prognosis in patients with heart failure with reduced ejection fraction (HFrEF).
A total of 521 patients (72% male; mean age: 67 ± 13 years) diagnosed with HFrEF were retrospectively analyzed. Clinical, demographic, laboratory, and echocardiographic data were collected. SII scores were calculated for all patients, and their prognostic significance and clinical outcomes were evaluated.
521 patients were analyzed. According to current findings, all-cause mortality occurred in 87 patient during the follow-up period. The mean SII in the mortality group was higher than in the survivors and was found to be statistically significant. (878.57 vs. 643.65; p = 0.003, respectively) In the multivariable regression model SII was found to be an independent risk factor for mortality. (p = 0.031) The AUC of SII for mortality prediction was 0.602 (95% CI = 0.531-0.673), the cut-off value was 729, and the sensitivity and specificity were 59.3% and 59.6% (p = 0.003).
This study demonstrates a significant association between SII and both survival and prognosis in patients with HFrEF. Notably, the SII index was found to be an independent predictor of mortality in this patient population.
全身免疫炎症指数（SII）是一种由血小板、中性粒细胞和淋巴细胞计数组合得出的新型标志物，已被证明与多种恶性肿瘤和炎症性疾病的不良临床结局相关。本研究旨在评估SII与射血分数降低的心力衰竭（HFrEF）患者疾病预后之间的关联。
回顾性分析了521例诊断为HFrEF的患者（72%为男性；平均年龄：67±13岁）。收集了临床、人口统计学、实验室和超声心动图数据。计算了所有患者的SII评分，并评估了其预后意义和临床结局。
对521例患者进行了分析。根据目前的研究结果，随访期间87例患者发生了全因死亡。死亡组的平均SII高于存活组，差异具有统计学意义。（分别为878.57和643.65；p = 0.003）在多变量回归模型中，SII被发现是死亡的独立危险因素。（p = 0.031）SII预测死亡的AUC为0.602（95%CI = 0.531 - 0.673），临界值为729，敏感性和特异性分别为59.3%和59.6%（p = 0.003）。
本研究表明SII与HFrEF患者的生存和预后均存在显著关联。值得注意的是，在该患者群体中，SII指数被发现是死亡的独立预测因子。
