Kayıkcı Gulce, Topçu Husna, Cetin Efe Ayse, Poslu Karademir Fatma, Ulas Mehmet Goksel
Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.
Department of Ophthalmology, Osmangazi Aritmi Hospital, Bursa, Turkey.
Clin Exp Optom. 2025 Aug;108(6):683-687. doi: 10.1080/08164622.2024.2399774. Epub 2024 Sep 9.
The role and prognostic significance of systemic inflammatory markers in various malignancies have been the subject of investigation. The role of these inflammatory markers in eyelid lesions remains to be elucidated.
Benign and malignant lesions of the eyelid are common presentations in eye clinics. Systemic inflammatory markers derived from a complete blood count may provide insight into the benign-malignant differentiation of the lesion.
This study included 134 patients who underwent surgery for eyelid lesions between 2021-2023. The lesions were evaluated by oculoplastic surgeons and operated on with a preliminary diagnosis of benign or malignant. According to the histopathological diagnosis, benign lesions were included in Group 1 and malignant lesions in Group 2. The neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and systemic immune inflammation index (SII) (NxP/L) based on neutrophil, lymphocyte, and platelet counts were calculated from the preoperative complete blood count of all patients.
Eighty-eight patients were included in Group 1 and 46 patients in Group 2. There were 41/47 (Female/Male) in Group 1 and 19/27 (F/M) males in Group 2 ( = 0.345). The mean age was 62.91 ± 9.04 years in Group 1 and 65.41 ± 8.76 years in Group 2 ( = 0.127). The preliminary diagnosis and histopathological diagnosis were incompatible in 5 cases in both groups. In Group 1: NLR = 1.82 ± 0.72, PLR = 124.50 ± 45.19 and SII = 454.51 ± 220.20, in Group 2: NLR = 2.48 ± 0.89, PLR = 128.12 ± 49.58 and SII = 590.22 ± 271.09. NLR and SII differences between groups were statistically significant, while PLR was similar ( < 0.001, = .002, = .671). ROC curve analysis showed that the optimal cut-off values for NLR, PLR, and SII were 1.99, 119.16, and 475.21, respectively.
High levels of NLR and SII in eyelid tumours can be used as an adjunct to examination findings in the preliminary diagnosis of the lesion as benign or malignant and may influence surgical planning.
全身炎症标志物在各种恶性肿瘤中的作用和预后意义一直是研究的主题。这些炎症标志物在眼睑病变中的作用仍有待阐明。
眼睑的良性和恶性病变是眼科诊所常见的病症。全血细胞计数得出的全身炎症标志物可能有助于了解病变的良恶性分化。
本研究纳入了2021年至2023年间接受眼睑病变手术的134例患者。病变由眼整形外科医生评估，并在初步诊断为良性或恶性后进行手术。根据组织病理学诊断，良性病变纳入第1组，恶性病变纳入第2组。根据所有患者术前全血细胞计数计算中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及基于中性粒细胞、淋巴细胞和血小板计数的全身免疫炎症指数（SII）（N×P/L）。
第1组纳入88例患者，第2组纳入46例患者。第1组有41/47（女性/男性），第2组有19/27（女性/男性）（P = 0.345）。第1组的平均年龄为62.91±9.04岁，第2组为65.41±8.76岁（P = 0.127）。两组均有5例患者的初步诊断与组织病理学诊断不相符。第1组：NLR = 1.82±0.72，PLR = 124.50±45.19，SII = 454.51±220.20；第2组：NLR = 2.48±0.89，PLR = 128.12±49.58，SII = 590.22±271.09。两组之间的NLR和SII差异具有统计学意义，而PLR相似（P < 0.001，P = 0.00），P = 0.671）。ROC曲线分析显示，NLR、PLR和SII的最佳截断值分别为1.99、119.16和475.21。
眼睑肿瘤中高水平的NLR和SII可作为病变初步诊断为良性或恶性时辅助检查结果的指标，并可能影响手术规划。
