Parveen P Roshan, Pavithra R, Sudha M, Chander R Vimal, Prakashiny S
Department of Pathology, ACS Medical College and Hospital, Chennai, Tamil Nadu, India.
Niger Postgrad Med J. 2025 Jul 1;32(3):187-191. doi: 10.4103/npmj.npmj_42_25. Epub 2025 Aug 1.
Varicose veins are a common condition affecting millions of people worldwide. While they are often considered primarily a cosmetic issue, varicose veins can also lead to pain, swelling, and discomfort. Histopathological studies are valuable for examining the structure and composition of varicose veins. These studies provide important insights into the underlying causes of the condition and help inform treatment options for patients.
To evaluate the distribution of collagen and elastin in the venous walls using Masson's Trichrome and Verhoeff's Van Gieson staining.
This study examines histological changes in varicose veins, focusing on the distribution of collagen and elastin through Masson's Trichrome and Verhoeff's Van Gieson staining methods. This study examined histological samples of varicose veins from 30 individuals. The tissue samples were fixed in formalin and stained with Hematoxylin & Eosin, Masson's Trichrome, and Verhoeff's Van Gieson stains, followed by analysis using light microscopy. Statistical analysis was performed with IBM SPSS version 23.0.
Histological evaluation revealed significant changes in the tunica media, including a loss of smooth muscle (86.67%) and increased collagen deposition (76.67%). The intima exhibited prevalent intimal thickening (96.67%) and fibrosis (93.33%), while the adventitia showed notable adventitial fibrosis (86.67%) and vascular remodeling (53.33%). Elastic fiber impairment was observed in 13.33% of individuals, with collagen as the main structural component in all venous layers.
Histopathological studies offer valuable insights into the structural changes that occur in varicose veins through the use of special stains. These studies play a crucial role in the diagnosis and management of varicose veins by providing detailed information about tissue structure and pathology. This information helps healthcare providers deliver personalized care to patients affected by this condition. Continued research in this field will further enhance our understanding of varicose veins and improve patient outcomes.
静脉曲张是一种常见病症，影响着全球数百万人。虽然它们通常主要被视为一个美容问题，但静脉曲张也会导致疼痛、肿胀和不适。组织病理学研究对于检查静脉曲张的结构和组成很有价值。这些研究为该病症的潜在病因提供了重要见解，并有助于为患者提供治疗方案。
使用马森三色染色法和韦尔霍夫-范吉森染色法评估静脉壁中胶原蛋白和弹性蛋白的分布。
本研究通过马森三色染色法和韦尔霍夫-范吉森染色法，研究静脉曲张的组织学变化，重点关注胶原蛋白和弹性蛋白的分布。本研究检查了30名个体的静脉曲张组织学样本。组织样本用福尔马林固定，并用苏木精和伊红、马森三色和韦尔霍夫-范吉森染色，然后使用光学显微镜进行分析。使用IBM SPSS 23.0版本进行统计分析。
组织学评估显示中膜有显著变化，包括平滑肌减少（86.67%）和胶原蛋白沉积增加（76.67%）。内膜普遍存在内膜增厚（96.67%）和纤维化（93.33%），而外膜显示明显的外膜纤维化（86.67%）和血管重塑（53.33%）。在13.33%的个体中观察到弹性纤维损伤，胶原蛋白是所有静脉层的主要结构成分。
组织病理学研究通过使用特殊染色法，为静脉曲张中发生的结构变化提供了有价值的见解。这些研究通过提供有关组织结构和病理学的详细信息，在静脉曲张的诊断和管理中发挥着关键作用。这些信息有助于医疗保健提供者为受该病症影响的患者提供个性化护理。该领域的持续研究将进一步加深我们对静脉曲张的理解，并改善患者的治疗效果。
