腺苷可刺激人体的呼吸。
Adenosine stimulates respiration in man.
作者信息
Watt A H, Routledge P A
出版信息
Br J Clin Pharmacol. 1985 Nov;20(5):503-6. doi: 10.1111/j.1365-2125.1985.tb05108.x.
Abstract
Respiratory effects produced by a series of intravenous boluses of adenosine were studied in nine healthy human subjects. Adenosine produced a significant dose-related increase in respiration, mostly due to increased depth of respiration. Possible mechanisms of this effect are discussed.
摘要
在9名健康人体受试者中研究了一系列静脉推注腺苷所产生的呼吸效应。腺苷使呼吸显著增加，且与剂量相关，这主要是由于呼吸深度增加所致。文中讨论了这种效应可能的机制。
相似文献
1
Adenosine stimulates respiration in man.腺苷可刺激人体的呼吸。
Br J Clin Pharmacol. 1985 Nov;20(5):503-6. doi: 10.1111/j.1365-2125.1985.tb05108.x.
2
Intravenous infusion of adenosine but not inosine stimulates respiration in man.静脉注射腺苷而非肌苷可刺激人体呼吸。
Br J Clin Pharmacol. 1987 Mar;23(3):331-8. doi: 10.1111/j.1365-2125.1987.tb03053.x.
3
Adenosine-induced respiratory stimulation in man depends on site of infusion. Evidence for an action on the carotid body?腺苷对人体呼吸的刺激作用取决于输注部位。是否有作用于颈动脉体的证据？
Br J Clin Pharmacol. 1987 Apr;23(4):486-90. doi: 10.1111/j.1365-2125.1987.tb03081.x.
4
Respiratory stimulant effects of adenosine in man after caffeine and enprofylline.咖啡因和恩丙茶碱后腺苷对人体的呼吸刺激作用。
Br J Clin Pharmacol. 1987 Dec;24(6):816-9. doi: 10.1111/j.1365-2125.1987.tb03251.x.
5
Adenosine-induced respiratory and heart rate changes in young and elderly adults.腺苷诱导的年轻人和老年人呼吸及心率变化。
Br J Clin Pharmacol. 1989 Feb;27(2):265-7. doi: 10.1111/j.1365-2125.1989.tb05360.x.
6
Comparison of respiratory effects of intravenous adenosine in neonatal and adult rabbits.新生兔和成年兔静脉注射腺苷的呼吸效应比较。
Life Sci. 1986 Nov 3;39(18):1617-22. doi: 10.1016/0024-3205(86)90157-8.
7
Transient bradycardia and subsequent sinus tachycardia produced by intravenous adenosine in healthy adult subjects.健康成年受试者静脉注射腺苷后出现的短暂性心动过缓和随后的窦性心动过速。
Br J Clin Pharmacol. 1986 May;21(5):533-6. doi: 10.1111/j.1365-2125.1986.tb02838.x.
8
Acute haemodynamic effects of intravenous infusion of adenosine in conscious man.静脉输注腺苷对清醒人体的急性血流动力学影响。
Eur Heart J. 1990 Nov;11(11):1018-28. doi: 10.1093/oxfordjournals.eurheartj.a059629.
9
Intravenous adenosine but not its first metabolite inosine provokes chest pain in healthy volunteers.
J Cardiovasc Pharmacol. 1990 Jul;16(1):173-6. doi: 10.1097/00005344-199007000-00023.
10
Circulatory and respiratory effects of infused adenosine in conscious man.清醒人体中输注腺苷对循环和呼吸的影响。
Br J Clin Pharmacol. 1987 Sep;24(3):309-17. doi: 10.1111/j.1365-2125.1987.tb03174.x.
引用本文的文献
1
Respiration-related variations in Pd/Pa ratio and fractional flow reserve in resting conditions and during intravenous adenosine administration.静息状态下及静脉注射腺苷时 Pd/Pa 比值和血流储备分数与呼吸相关的变化。
Catheter Cardiovasc Interv. 2022 Feb;99(3):844-852. doi: 10.1002/ccd.30012. Epub 2021 Nov 12.
2
Cardiorespiratory Effects of Three Infusion Doses of Adenosine in Conscious Goats: A Preliminary Study.三种输注剂量腺苷对清醒山羊心肺功能的影响：一项初步研究。
Vet Sci. 2021 Aug 6;8(8):158. doi: 10.3390/vetsci8080158.
3
Gating Approaches in Cardiac PET Imaging.心脏PET成像中的门控方法
PET Clin. 2019 Apr;14(2):271-279. doi: 10.1016/j.cpet.2018.12.008. Epub 2019 Feb 1.
4
Purines and Carotid Body: New Roles in Pathological Conditions.嘌呤与颈动脉体：病理状态下的新作用。
Front Pharmacol. 2017 Dec 12;8:913. doi: 10.3389/fphar.2017.00913. eCollection 2017.
5
Impact of pharmacological stress agent on patient motion during rubidium-82 myocardial perfusion PET/CT.锶-82 心肌灌注 PET/CT 检查中药物负荷剂对患者运动的影响。
J Nucl Cardiol. 2018 Aug;25(4):1286-1295. doi: 10.1007/s12350-016-0767-x. Epub 2017 Jan 4.
6
Effects of selective carotid body stimulation with adenosine in conscious humans.清醒人类中腺苷选择性刺激颈动脉体的作用。
J Physiol. 2016 Nov 1;594(21):6225-6240. doi: 10.1113/JP272109. Epub 2016 Sep 11.
7
A review of 3D first-pass, whole-heart, myocardial perfusion cardiovascular magnetic resonance.三维首过全心心肌灌注心血管磁共振综述
J Cardiovasc Magn Reson. 2015 Aug 1;17(1):68. doi: 10.1186/s12968-015-0162-9.
8
Characterization of spontaneous, transient adenosine release in the caudate-putamen and prefrontal cortex.纹状体和前额叶皮质中自发、短暂的腺苷释放特征。
PLoS One. 2014 Jan 29;9(1):e87165. doi: 10.1371/journal.pone.0087165. eCollection 2014.
9
Peripheral chemoreceptors: function and plasticity of the carotid body.外周化学感受器：颈动脉体的功能和可塑性。
Compr Physiol. 2012 Jan;2(1):141-219. doi: 10.1002/cphy.c100069.
10
Adenosine-induced activation of esophageal nociceptors.腺苷诱导食管伤害感受器激活。
Am J Physiol Gastrointest Liver Physiol. 2011 Mar;300(3):G485-93. doi: 10.1152/ajpgi.00361.2010. Epub 2010 Dec 9.
本文引用的文献
1
The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart.腺嘌呤化合物的生理活性，特别涉及其对哺乳动物心脏的作用。
J Physiol. 1929 Nov 25;68(3):213-37. doi: 10.1113/jphysiol.1929.sp002608.
2
Carotid bodies and ventilatory control dynamics in man.人体中的颈动脉体与通气控制动力学
Fed Proc. 1980 Jul;39(9):2668-73.
3
Effect of adenosine on carotid chemoreceptor activity in the cat.腺苷对猫颈动脉化学感受器活动的影响。
Br J Pharmacol. 1981 Sep;74(1):129-36. doi: 10.1111/j.1476-5381.1981.tb09964.x.
4
Distribution of oxygen partial pressure in the carotid body region and in the carotid body (rabbit).颈动脉体区域及颈动脉体（兔）内氧分压的分布
Pflugers Arch. 1980 Nov;388(2):137-42. doi: 10.1007/BF00584119.
5
Regulation of breathing in the rat: indications for a role of central adenosine mechanisms.大鼠呼吸的调节：中枢腺苷机制作用的指征
Neurosci Lett. 1982 Nov 30;33(2):147-51. doi: 10.1016/0304-3940(82)90242-7.
6
Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia.腺苷：电生理效应及用于终止阵发性室上性心动过速的治疗用途。
Circulation. 1983 Dec;68(6):1254-63. doi: 10.1161/01.cir.68.6.1254.
7
Dipyridamole inhibition of adenosine metabolism in human blood.双嘧达莫对人体血液中腺苷代谢的抑制作用。
Eur J Pharmacol. 1983 Sep 16;93(1-2):21-6. doi: 10.1016/0014-2999(83)90026-2.
8
Respiratory effects of a long-acting analog of adenosine.
Brain Res. 1984 Jun 3;301(2):273-80. doi: 10.1016/0006-8993(84)91096-5.
9
Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors?
Pediatr Res. 1984 Apr;18(4):387-90. doi: 10.1203/00006450-198404000-00018.
10
On the specificity and type of receptor involved in carotid body chemoreceptor activation by adenosine in the cat.关于猫体内腺苷激活颈动脉体化学感受器所涉及的受体特异性和类型
Br J Pharmacol. 1983 Oct;80(2):347-54. doi: 10.1111/j.1476-5381.1983.tb10040.x.
Zotero 插件