腺苷对人体呼吸的刺激作用取决于输注部位。是否有作用于颈动脉体的证据？
Adenosine-induced respiratory stimulation in man depends on site of infusion. Evidence for an action on the carotid body?
作者信息
Watt A H, Reid P G, Stephens M R, Routledge P A
出版信息
Br J Clin Pharmacol. 1987 Apr;23(4):486-90. doi: 10.1111/j.1365-2125.1987.tb03081.x.
Abstract
Adenosine is an endogenous nucleoside which stimulates respiration in man and other mammals. In animals adenosine appears to initiate respiratory stimulation within the carotid body, but whether this is the site of action in man is not known. We administered adenosine by intra-aortic infusion to 12 subjects undergoing cardiac catheterisation. When adenosine was infused at three sites proximal to the carotid circulation, minute ventilation was significantly higher than baseline values or those during adenosine infusion at a more distal site. These results support the hypothesis that adenosine-induced respiratory stimulation in man is mediated in the carotid body.
摘要
腺苷是一种内源性核苷，可刺激人类和其他哺乳动物的呼吸。在动物体内，腺苷似乎在颈动脉体中引发呼吸刺激，但这是否是其在人体内的作用部位尚不清楚。我们通过主动脉内输注向12名接受心导管检查的受试者给药腺苷。当在颈动脉循环近端的三个部位输注腺苷时，分钟通气量显著高于基线值或在更远端部位输注腺苷时的值。这些结果支持了这样一种假说，即腺苷在人体内引起的呼吸刺激是由颈动脉体介导的。
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本文引用的文献
1
The effects of stimulation of the carotid body chemoreceptors on heart rate in the dog.刺激犬颈动脉体化学感受器对心率的影响。
J Physiol. 1958 Nov 10;144(1):148-66. doi: 10.1113/jphysiol.1958.sp006092.
2
Effect of adenosine on sinoatrial and ventricular automaticity of the guinea pig.腺苷对豚鼠窦房结和心室自律性的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Mar;311(2):147-9. doi: 10.1007/BF00510253.
3
Hypotensive effects of adenosine and adenosine triphosphate compared with sodium nitroprusside.腺苷和三磷酸腺苷与硝普钠相比的降压作用。
Anesth Analg. 1982 Mar;61(3):273-8.
4
Dipyridamole inhibition of adenosine metabolism in human blood.双嘧达莫对人体血液中腺苷代谢的抑制作用。
Eur J Pharmacol. 1983 Sep 16;93(1-2):21-6. doi: 10.1016/0014-2999(83)90026-2.
5
Controlled hypotension with adenosine in cerebral aneurysm surgery.腺苷用于脑动脉瘤手术中的控制性低血压
Anesthesiology. 1984 Oct;61(4):400-5. doi: 10.1097/00000542-198410000-00007.
6
Attempted antagonism of adenosine analogue induced depression of respiration.腺苷类似物诱导的呼吸抑制的拮抗尝试。
Pharmacol Biochem Behav. 1984 Aug;21(2):289-96. doi: 10.1016/0091-3057(84)90228-4.
7
Respiratory effects of a long-acting analog of adenosine.
Brain Res. 1984 Jun 3;301(2):273-80. doi: 10.1016/0006-8993(84)91096-5.
8
The role of adenosine in the regulation of coronary blood flow.腺苷在冠状动脉血流调节中的作用。
Circ Res. 1980 Dec;47(6):807-13. doi: 10.1161/01.res.47.6.807.
9
The relative roles of the aortic and carotid sinus nerves in the rabbit in the control of respiration and circulation during arterial hypoxia and hypercapnia.兔的主动脉神经和颈动脉窦神经在动脉低氧和高碳酸血症期间对呼吸和循环控制中的相对作用。
J Physiol. 1967 Feb;188(3):435-50. doi: 10.1113/jphysiol.1967.sp008148.
10
Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man.双侧颈动脉体切除对人体静息和运动时通气控制的影响。
N Engl J Med. 1971 Nov 11;285(20):1105-11. doi: 10.1056/NEJM197111112852002.
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