Addressing the silent threat: managing invasive infections in hospitalized newborns.

Invasive fungal infections (IFIs) remain an important problem for hospitalized newborn infants receiving intensive care, given their substantial morbidity and mortality. species ( spp.) are the major fungal pathogens, which cause the so-called invasive infections (ICIs). Of these, is the most commonly isolated species, followed by . Other identified spp. include , , , etc. However, an increasing shift in the epidemiology of ICIs worldwide has been described, non- (NAC) spp. ICIs pose a growing threat to neonates. Herein, we examine the epidemiology of spp. infections, patterns of antifungal resistance, risk factors, prevention strategies, clinical outcomes, and treatment recommendations for ICIs in hospitalized newborn infants. This review aims to provide a thorough understanding of the current evidence on ICIs to better inform targeted prevention strategies and improved treatments to reduce neonatal morbidity and mortality.