Blum Kenneth, Braverman Eric R, Sharafshah Alireza, Elman Igor, Lewandrowski Kai-Uwe, Bowirrat Abdalla, Pinhasov Albert, Thanos Panayotis K, Gold Mark S, Dennen Catherine A, Modestino Edward J, Badgaiyan Rajendra D, Baron David, Fuehrlein Brian, Sipple Daniel, Ashford John Wesson, Sunder Keerthy, Makale Milan, Murphy Kevin, Jafari Nicole, Zeine Foojan, Pollack Aryeh R, Lewandrowski Alexander P L, Khalsa Jag
Division of Clinical Neurology, The Blum Institute of Neurogenetics and Behavior, Austin, Texas, United States of America.
Division of Personalized Pain Therapy Research and Education, Center for Advanced Spine Care of Southern Arizona, Tucson, Arizona, United States of America.
Gene Protein Dis. 2025 Jun 3;5. doi: 10.36922/gpd.6557.
Artificially increasing dopamine transmission is the common mechanism by which substances with addictive potential lead to addiction. A key area of research in neurobiology is the role of dopamine. Significant advancements have been made in uncovering the intracellular signaling pathways that mediate both dopamine's immediate effects and its long-term influence on brain function. Recent discoveries have also highlighted specific molecules that could serve as potential therapeutic targets for neurological and psychiatric disorders. While understanding several important caveats, we believe dopamine acts as a master regulator of brain circuitry across major chromosomes mapping the mental health genome. This view may have important clinical relevance, emphasizing the critical role of dopaminergic activity across the genome. Importantly, we are cognizant that dopamine does not work in insolation, and its finite actions are due to a highly interactive network (known as the brain reward cascade), involving at least seven other major neurotransmitters.
人为增加多巴胺传递是具有成瘾潜力的物质导致成瘾的共同机制。神经生物学研究的一个关键领域是多巴胺的作用。在揭示介导多巴胺即时效应及其对脑功能长期影响的细胞内信号通路方面已取得重大进展。最近的发现还突出了一些特定分子，它们可能成为神经和精神疾病的潜在治疗靶点。尽管要理解几个重要的注意事项，但我们认为多巴胺是跨主要染色体映射心理健康基因组的脑回路的主要调节因子。这一观点可能具有重要的临床意义，强调了整个基因组中多巴胺能活动的关键作用。重要的是，我们认识到多巴胺并非独立起作用，其有限的作用归因于一个高度相互作用的网络（称为脑奖赏级联），该网络至少涉及其他七种主要神经递质。
