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利用超声造影检测肝移植术后的胆道并发症。

Detecting biliary complications following liver transplantation with contrast-enhanced ultrasound.

作者信息

Zhang Yu, Hao Jing, Luo Zi, Li Yi-Jun, Liu Zhong, Zhao Ning-Bo

机构信息

Department of Ultrasound, National Clinical Research Centre for Infectious Disease, Shenzhen Third People's Hospital, The Second Hospital Affiliated with Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China.

Department of Digestive Medicine, The First Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100853, China.

出版信息

World J Radiol. 2025 Jul 28;17(7):106556. doi: 10.4329/wjr.v17.i7.106556.

DOI:10.4329/wjr.v17.i7.106556
PMID:40746515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12308602/
Abstract

Liver transplantation is the primary therapeutic choice for end-stage liver disease. Currently, biliary complications are among the main factors affecting the survival rate and quality of life of liver transplant recipients. Nevertheless, the clinical manifestations of biliary complications following liver transplantation are often non-specific, making early diagnosis and timely treatment crucial for improving patient outcomes. Ultrasound is the preferred imaging method following liver transplantation. Importantly, contrast-enhanced ultrasound, with the administration of contrast agents, can improve the resolution of biliary images and enable real-time, dynamic visualization of microcirculation perfusion in the biliary system and surrounding tissues. The present article describes the normal ultrasonic features of the biliary system following liver transplantation and briefly reviews the progress in the ultrasonic diagnosis of common biliary complications, including anastomotic biliary strictures, non-anastomotic biliary strictures, biliary leakage, biloma, and bile sludge/bile stone.

摘要

肝移植是终末期肝病的主要治疗选择。目前,胆道并发症是影响肝移植受者生存率和生活质量的主要因素之一。然而,肝移植后胆道并发症的临床表现往往不具有特异性,因此早期诊断和及时治疗对于改善患者预后至关重要。超声是肝移植后首选的影像学检查方法。重要的是,超声造影通过注入造影剂,可提高胆道图像的分辨率,并能实时、动态地显示胆道系统及周围组织的微循环灌注情况。本文介绍了肝移植后胆道系统的正常超声特征,并简要综述了常见胆道并发症,包括吻合口胆管狭窄、非吻合口胆管狭窄、胆漏、胆汁瘤和胆泥/胆结石的超声诊断进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/669890b47ffa/wjr-17-7-106556-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/6209f3aa2e42/wjr-17-7-106556-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/401230bd00d1/wjr-17-7-106556-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/095e35d41c94/wjr-17-7-106556-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/b439af921da1/wjr-17-7-106556-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/e35415a27580/wjr-17-7-106556-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/669890b47ffa/wjr-17-7-106556-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/6209f3aa2e42/wjr-17-7-106556-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/401230bd00d1/wjr-17-7-106556-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/095e35d41c94/wjr-17-7-106556-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/b439af921da1/wjr-17-7-106556-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/e35415a27580/wjr-17-7-106556-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3889/12308602/669890b47ffa/wjr-17-7-106556-g006.jpg

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1
Detecting biliary complications following liver transplantation with contrast-enhanced ultrasound.利用超声造影检测肝移植术后的胆道并发症。
World J Radiol. 2025 Jul 28;17(7):106556. doi: 10.4329/wjr.v17.i7.106556.
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本文引用的文献

1
Ultrasound innovations in abdominal radiology: multiparametic imaging in liver transplantation.腹部放射学中的超声创新:肝移植中的多参数成像
Abdom Radiol (NY). 2025 Feb;50(2):679-692. doi: 10.1007/s00261-024-04518-y. Epub 2024 Aug 21.
2
Prediction of hepatic artery occlusion after liver transplantation by ultrasound characteristics and clinical risk factors.通过超声特征和临床危险因素预测肝移植术后肝动脉闭塞
World J Radiol. 2024 Jun 28;16(6):196-202. doi: 10.4329/wjr.v16.i6.196.
3
The role of CEUS in the management of biloma.
CEUS 在胆漏管理中的作用。
J Ultrasound. 2024 Sep;27(3):745-749. doi: 10.1007/s40477-023-00849-6. Epub 2024 Feb 8.
4
Radiologic findings of biliary complications post liver transplantation.肝移植术后胆道并发症的放射学表现。
Abdom Radiol (NY). 2023 Jan;48(1):166-185. doi: 10.1007/s00261-022-03714-y. Epub 2022 Oct 26.
5
Persistent biliary hypoxia and lack of regeneration are key mechanisms in the pathogenesis of posttransplant nonanastomotic strictures.持续性胆汁缺氧和再生缺乏是移植后非吻合口狭窄发病机制中的关键机制。
Hepatology. 2022 Apr;75(4):814-830. doi: 10.1002/hep.32166. Epub 2021 Dec 11.
6
RISK FACTORS FOR POST-LIVER TRANSPLANT BILIARY COMPLICATIONS IN THE ABSENCE OF ARTERIAL COMPLICATIONS.无动脉并发症情况下肝移植术后胆道并发症的危险因素
Arq Bras Cir Dig. 2020 Dec 18;33(3):e1541. doi: 10.1590/0102-672020200003e1541. eCollection 2020.
7
Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver - Update 2020 - WFUMB in Cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS.肝脏对比增强超声(CEUS)临床实践指南和良好规范推荐 - 2020 年更新版 - WFUMB 联合 EFSUMB、AFSUMB、AIUM 和 FLAUS 制定。
Ultraschall Med. 2020 Oct;41(5):562-585. doi: 10.1055/a-1177-0530. Epub 2020 Jul 24.
8
Biliary Complications After Liver Transplantation From Uncontrolled Donors After Circulatory Death: Incidence, Management, and Outcome.《无心跳供体肝移植术后胆系并发症:发生率、处理及预后》
Liver Transpl. 2020 Jan;26(1):80-91. doi: 10.1002/lt.25646. Epub 2019 Nov 1.
9
Contrast-enhanced ultrasound for quantification of tissue perfusion in humans.超声造影在人体组织灌注定量中的应用。
Microcirculation. 2020 Jan;27(1):e12588. doi: 10.1111/micc.12588. Epub 2019 Sep 17.
10
Comprehensive review on EUS-guided biliary drainage.内镜超声引导下胆道引流的综合综述
World J Gastrointest Endosc. 2019 May 16;11(5):354-364. doi: 10.4253/wjge.v11.i5.354.