Liu Yukun, Lei Yanqi, Dai Zhuojun, Luo Changfang, Gong Qiming, Li Yanqun, Xu Yong, Huang Wei
Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Clinical Medical College of Southwest Medical University, Luzhou, China.
Front Immunol. 2025 Jul 17;16:1613602. doi: 10.3389/fimmu.2025.1613602. eCollection 2025.
Recent studies have revealed that the innate immune system possesses the capacity to develop "trained immunity" via metabolic and epigenetic reprogramming, leading to non-specific memory responses distinct from the memory traditionally attributed exclusively to adaptive immunity. Hyperglycemia, acting as an initiating stimulus, drives myeloid progenitor cell proliferation and monocyte-derived macrophage expansion, which leads to a sustained pro-inflammatory phenotype that is closely associated with the pathogenesis of diabetes and its related complications. The paradigm of trained immunity provides a novel perspective on explaining the "metabolic memory" phenomenon in diabetes. Here, we summarize the research progress on trained immunity, diabetes, and related complications to explore novel insights into diabetes prevention and treatment.
最近的研究表明，先天免疫系统具有通过代谢和表观遗传重编程来产生“训练有素的免疫”的能力，从而导致与传统上仅归因于适应性免疫的记忆不同的非特异性记忆反应。高血糖作为一种起始刺激，驱动髓系祖细胞增殖和单核细胞衍生的巨噬细胞扩张，这导致一种持续的促炎表型，该表型与糖尿病及其相关并发症的发病机制密切相关。训练有素的免疫范式为解释糖尿病中的“代谢记忆”现象提供了一个新的视角。在此，我们总结了关于训练有素的免疫、糖尿病及相关并发症的研究进展，以探索糖尿病预防和治疗的新见解。
