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肾移植术后患者使用铁羧麦芽糖增强磁共振血管造影术进行血管腔内主动脉修复监测

Ferumoxytol-enhanced magnetic resonance angiography for endovascular aortic repair surveillance in a patient after renal transplant.

作者信息

Li Richard Longfei, Ludwig Daniel R, Shetty Anup S, Mellnick Vincent, Rubin Brian G

机构信息

Division of Vascular Surgery, WashU Medicine, St Louis, MO.

Malinkrodt Institute of Radiology, WashU Medicine, St Louis, MO.

出版信息

J Vasc Surg Cases Innov Tech. 2025 Jun 26;11(5):101898. doi: 10.1016/j.jvscit.2025.101898. eCollection 2025 Oct.

DOI:10.1016/j.jvscit.2025.101898
PMID:40746975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12311432/
Abstract

Endovascular aneurysm repair requires lifelong imaging surveillance, typically with contrast-enhanced computed tomography imaging. This poses risks to patients with end-stage renal disease. Ferumoxytol, a superparamagnetic iron-based nanoparticle with minimal nephrotoxicity, has emerged as an alternative contrast agent for magnetic resonance angiography in patients with renal impairment. We present a case of a patient with a failing renal transplant who underwent ferumoxytol-enhanced magnetic resonance angiography to further characterize an indeterminant etiology of continued aneurysm sac expansion to 10 cm, avoiding iodinated and gadolinium-based contrast while achieving high-quality imaging for endoleak detection.

摘要

血管内动脉瘤修复需要终身影像学监测,通常采用对比增强计算机断层扫描成像。这给终末期肾病患者带来了风险。非洛铁是一种具有最小肾毒性的超顺磁性铁基纳米颗粒,已成为肾功能损害患者磁共振血管造影的替代造影剂。我们报告了一例肾移植失败的患者,该患者接受了非洛铁增强磁共振血管造影,以进一步明确持续动脉瘤囊扩张至10厘米的不确定病因,避免使用含碘和钆基造影剂,同时获得用于检测内漏的高质量成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f599/12311432/2761407d8dca/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f599/12311432/13abc5a00db5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f599/12311432/2761407d8dca/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f599/12311432/13abc5a00db5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f599/12311432/2761407d8dca/gr2.jpg

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本文引用的文献

1
Evaluation of aortic stent endoleaks in the renally impaired patient with ferumoxytol-enhanced MR angiography.使用铁羧麦芽糖增强磁共振血管造影术评估肾功能受损患者的主动脉支架内漏。
Clin Imaging. 2025 Feb;118:110383. doi: 10.1016/j.clinimag.2024.110383. Epub 2024 Dec 5.
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Review of Clinical Applications of Dual-Energy CT in Patients after Endovascular Aortic Repair.血管腔内主动脉修复术后患者双能量CT的临床应用综述
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Ferumoxytol-Enhanced MRI in Children and Young Adults: State of the Art.
铁氧体增强 MRI 在儿童和青少年中的应用:现状。
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Chronic kidney disease measures and the risk of abdominal aortic aneurysm.慢性肾脏病评估与腹主动脉瘤风险。
Atherosclerosis. 2018 Dec;279:107-113. doi: 10.1016/j.atherosclerosis.2018.08.043. Epub 2018 Sep 1.
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The Society for Vascular Surgery practice guidelines on follow-up after vascular surgery arterial procedures.血管外科学会关于血管手术后随访的实践指南。
J Vasc Surg. 2018 Jul;68(1):256-284. doi: 10.1016/j.jvs.2018.04.018.
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Contrast-induced nephropathy: Pathophysiology, risk factors, and prevention.造影剂肾病:病理生理学、危险因素及预防
Saudi J Kidney Dis Transpl. 2018 Jan-Feb;29(1):1-9. doi: 10.4103/1319-2442.225199.
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Current and potential imaging applications of ferumoxytol for magnetic resonance imaging.菲洛米莫用于磁共振成像的当前及潜在成像应用
Kidney Int. 2017 Jul;92(1):47-66. doi: 10.1016/j.kint.2016.12.037. Epub 2017 Apr 20.
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Surveillance Imaging Following Endovascular Aneurysm Repair.血管内动脉瘤修复术后的监测成像
Semin Intervent Radiol. 2015 Sep;32(3):239-48. doi: 10.1055/s-0035-1556878.
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Vascular Imaging With Ferumoxytol as a Contrast Agent.以铁羧麦芽糖为造影剂的血管成像
AJR Am J Roentgenol. 2015 Sep;205(3):W366-73. doi: 10.2214/AJR.15.14534. Epub 2015 Jun 23.