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成功应用体外左心室辅助装置治疗伴有主动脉瓣反流的心源性休克作为手术过渡手段

Successful Use of Extracorporeal LVAD for Cardiogenic Shock with Aortic Valve Regurgitation as Bridge to Surgery.

作者信息

Taguchi Takura, Kawamura Takuji, Yoshioka Daisuke, Saito Shunsuke, Kawamura Ai, Misumi Yusuke, Miyagawa Shigeru

机构信息

Department of Cardiovascular Surgery, University of Osaka Graduate School of Medicine, Suita, Osaka, Japan.

出版信息

Surg Case Rep. 2025;11(1). doi: 10.70352/scrj.cr.25-0343. Epub 2025 Jul 26.

Abstract

INTRODUCTION

Intra-aortic balloon pumping (IABP), Impella, and veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are common percutaneous devices used to manage hemodynamic instability in patients with cardiogenic shock. These devices play a critical role in providing circulatory support. However, they may fail to achieve sufficient left ventricular unloading in patients with aortic valve regurgitation (AR), potentially complicating treatment strategies. In such challenging cases, an extracorporeal left ventricular assist device (LVAD) may serve as an effective alternative solution.

CASE PRESENTATION

A 61-year-old man presented with heart failure and cardiogenic shock, further complicated by AR. Despite intensive inotropic therapy, his condition deteriorated, leading to significant hepatic and renal dysfunction. Echocardiography revealed left ventricular dysfunction with an ejection fraction of 23.5%, as well as moderate aortic, mitral, and tricuspid valve regurgitation. Initial management with VA-ECMO proved inadequate, necessitating the implantation of an extracorporeal LVAD. This intervention resulted in marked improvements in hemodynamics and multi-organ function. Subsequently, the patient underwent successful surgical procedures, including aortic valve replacement, mitral and tricuspid annuloplasty, and pulmonary vein isolation. He was discharged on day 51.

CONCLUSIONS

This case highlights the challenges in managing cardiogenic shock with AR, where conventional devices like IABP, Impella, and VA-ECMO may exacerbate the condition. The use of an extracorporeal LVAD provided effective left ventricular unloading, enabling successful preoperative optimization and surgery. This case supports the utility of LVAD as a bridge to surgery in patients with cardiogenic shock and AR, suggesting a need for further research into optimal management strategies in such complex cases.

摘要

引言

主动脉内球囊反搏(IABP)、Impella和静脉-动脉体外膜肺氧合(VA-ECMO)是用于治疗心源性休克患者血流动力学不稳定的常见经皮装置。这些装置在提供循环支持方面发挥着关键作用。然而,对于主动脉瓣反流(AR)患者,它们可能无法实现足够的左心室卸载,这可能会使治疗策略复杂化。在这种具有挑战性的情况下,体外左心室辅助装置(LVAD)可能是一种有效的替代解决方案。

病例介绍

一名61岁男性因心力衰竭和心源性休克就诊,并发AR。尽管进行了强化的正性肌力药物治疗,他的病情仍恶化,导致严重的肝肾功能障碍。超声心动图显示左心室功能障碍,射血分数为23.5%,同时存在中度主动脉瓣、二尖瓣和三尖瓣反流。最初使用VA-ECMO的治疗效果不佳,因此需要植入体外LVAD。这一干预使血流动力学和多器官功能得到显著改善。随后,患者成功接受了包括主动脉瓣置换、二尖瓣和三尖瓣瓣环成形术以及肺静脉隔离在内的手术。他在第51天出院。

结论

本病例突出了在AR患者中管理心源性休克的挑战,其中IABP、Impella和VA-ECMO等传统装置可能会使病情恶化。体外LVAD的使用提供了有效的左心室卸载,使术前优化和手术得以成功进行。本病例支持LVAD作为心源性休克和AR患者手术桥梁的实用性,表明需要进一步研究此类复杂病例的最佳管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df8e/12310382/f63a4923a053/scr-11-01-25-0343-g001.jpg

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