Wang Xi-Xi, Yan Chun, Wang Su-Juan, Zhu Hong, Cao Chang-Chun, Wu Li, Wang Shuang, Hu Ji, Zhang Hong-Hong
Department of Endocrinology, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian 223800, Jiangsu Province, China.
Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China.
World J Hepatol. 2025 Jul 27;17(7):109067. doi: 10.4254/wjh.v17.i7.109067.
Diabetic gastrointestinal autonomic neuropathy (DGAN) often affects the patients' quality of life. Thus, research on influencing factors of DGAN may promote DGAN prevention and decrease the incidence rate. This study used electrogastrogram (EGG) to assess the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and DGAN.
To analyze the changes of EGG in patients with MASLD and type 2 diabetes mellitus (T2DM), and to elucidate whether ultrasound-diagnosed MASLD is an independent risk factor for diabetic gastric motility disorders (DGMD).
A total of 272 patients with T2DM hospitalized at the Second Affiliated Hospital of Soochow University from December 2020 to December 2021 and the Affiliated Suqian Hospital of Xuzhou Medical University from November 2023 to June 2024 were included in the cross-sectional study. General information, clinical data, and medical history of all study subjects, including name, age, gender, body mass index, and duration of diabetes were collected. Laboratory tests included biochemical parameters, glycosylated hemoglobin (HbA1c), fasting C-peptide, 2h postprandial C-peptide and 25-hydroxyvitamin D [25(OH)D]. EGG, fundus examination and carotid artery ultrasonography were performed and results were recorded. According to the results of EGG, the subjects were divided into the DGMD group and non-DGMD group.
The duration of diabetes, fasting blood glucose (FBG), HbA1c, 25(OH)D and the prevalence of MASLD were significantly higher in the DGMD group ( < 0.05). Multiple logistic regression analysis showed that the duration, FBG, 25(OH)D and the presence of MASLD were independent influencing factors.
MASLD is strongly associated with an increased incidence of DGMD. Timely treatment of MASLD is effective to prevent diabetic gastroparesis.
糖尿病性胃肠自主神经病变（DGAN）常影响患者生活质量。因此，对DGAN影响因素的研究可能有助于预防DGAN并降低其发病率。本研究采用胃电图（EGG）评估代谢功能障碍相关脂肪性肝病（MASLD）与DGAN之间的关系。
分析MASLD合并2型糖尿病（T2DM）患者的EGG变化，阐明超声诊断的MASLD是否为糖尿病胃动力障碍（DGMD）的独立危险因素。
本横断面研究纳入了2020年12月至2021年12月在苏州大学附属第二医院以及2023年11月至2024年6月在徐州医科大学附属宿迁医院住院的272例T2DM患者。收集了所有研究对象的一般信息、临床资料和病史，包括姓名、年龄、性别、体重指数和糖尿病病程。实验室检查包括生化指标、糖化血红蛋白（HbA1c）、空腹C肽、餐后2小时C肽和25-羟基维生素D [25(OH)D]。进行了EGG、眼底检查和颈动脉超声检查并记录结果。根据EGG结果，将受试者分为DGMD组和非DGMD组。
DGMD组的糖尿病病程、空腹血糖（FBG）、HbA1c、25(OH)D和MASLD患病率显著更高（<0.05）。多因素logistic回归分析显示，病程、FBG、25(OH)D和MASLD的存在是独立影响因素。
MASLD与DGMD发病率增加密切相关。及时治疗MASLD对预防糖尿病胃轻瘫有效。
