Vatche and Tamar Manoukian Division of Digestive Diseases, G. Oppenheimer Center for Neurobiology of Stress and Resilience, Clinical Studies and Database Core, Goodman-Luskin Microbiome Center, David Geffen School of Medicine, University College Los Angeles, Los Angeles, CA, USA.
Lancet Gastroenterol Hepatol. 2024 Nov;9(11):1052-1064. doi: 10.1016/S2468-1253(24)00231-0. Epub 2024 Sep 20.
Gastroparesis is a disorder of delayed gastric emptying with associated symptoms of postprandial fullness, early satiety, nausea, vomiting, bloating, and abdominal pain. Functional dyspepsia is an upper gastrointestinal disorder of gut-brain interaction that presents with similar symptoms but is defined according to symptom patterns rather than gastric motor dysfunction. Although delayed gastric emptying is a defining feature of gastroparesis, other aspects of gastric neuromuscular dysfunction, such as gastric accommodation and visceral hypersensitivity might contribute to symptoms. Similarly, although functional dyspepsia is not defined by impaired gastric emptying, disordered gastric motility might underlie pathogenesis in some patients with functional dyspepsia. In the last decade, it has been increasingly recognised that these two disorders might represent varying presentations along a common continuum of neuromuscular dysfunction, although with differentiating features with respect to outcomes, diagnosis, and treatments. In this Review, an overview of gastroparesis and functional dyspepsia from the perspective of gastric motility is provided, discussing what is distinct and what is shared between these disorders.
胃轻瘫是一种胃排空延迟的疾病，伴有餐后饱胀、早饱、恶心、呕吐、腹胀和腹痛等症状。功能性消化不良是一种胃肠道-大脑相互作用的上消化道疾病，其表现出类似的症状，但根据症状模式而不是胃动力功能障碍来定义。虽然胃排空延迟是胃轻瘫的一个特征，但胃的神经肌肉功能的其他方面，如胃顺应性和内脏高敏性，可能与症状有关。同样，尽管功能性消化不良的定义不是排空受损，但在一些功能性消化不良患者中，异常的胃动力可能是发病机制的基础。在过去的十年中，人们越来越认识到，这两种疾病可能代表着神经肌肉功能障碍的共同连续体上的不同表现，尽管在结局、诊断和治疗方面存在不同的特征。在这篇综述中，从胃动力的角度提供了对胃轻瘫和功能性消化不良的概述，讨论了这些疾病之间的不同和相同之处。
