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结直肠癌中凝集素与蛋白质的存在及相互作用

Presence and Interactions of Lectin and Protein in Colorectal Cancer.

作者信息

Haghighi Leila, Dalimi Abdolhossein, Pirestani Majid, Ghaffarifar Fatemeh

机构信息

Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

出版信息

Iran J Parasitol. 2025 Apr-Jun;20(2):245-252. doi: 10.18502/ijpa.v20i2.19031.

Abstract

BACKGROUND

We aimed to analyze the presence of lectin light chain antigen and protein in colorectal cancer biopsies to uncover potential antigenic interactions between them.

METHODS

Overall, 150 colorectal cancer biopsy samples were subjected to examination for the specific antigen and protein through the application of the immunohistochemical technique. To augment diagnostic precision, the western blotting method was employed and its results were compared with those obtained from immunohistochemistry (IHC).

RESULTS

Among the 150 colorectal cancer biopsy samples examined, 100 cases tested positive for the protein, while 19 cases exhibited positivity for the light chain lectin antigen. Notably, only 14 cases demonstrated a positive presence for both the protein and the protozoan.

CONCLUSION

, a leading cause of parasitic infections, raises questions about its potential link to colorectal cancer, specifically in connection with the protein. The findings presented in this investigation signal the need for further research to comprehensively understand the implications of in colorectal cancer diagnosis and treatment strategies.

摘要

背景

我们旨在分析结直肠癌活检组织中凝集素轻链抗原和蛋白质的存在情况,以揭示它们之间潜在的抗原相互作用。

方法

总体而言,通过应用免疫组织化学技术,对150份结直肠癌活检样本进行了特定抗原和蛋白质的检测。为提高诊断准确性,采用了蛋白质印迹法,并将其结果与免疫组织化学(IHC)结果进行比较。

结果

在检测的150份结直肠癌活检样本中,100例蛋白质检测呈阳性,而19例凝集素轻链抗原呈阳性。值得注意的是,只有14例同时显示蛋白质和原生动物呈阳性。

结论

作为寄生虫感染的主要原因,引发了关于其与结直肠癌潜在联系的疑问,特别是与蛋白质相关。本研究结果表明需要进一步研究,以全面了解在结直肠癌诊断和治疗策略中的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e19/12307784/4cf1b329a962/IJPA-20-245-g001.jpg

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