Xiong Yan, Zhou Jie, Wang Junru, Huang Hui
Institute of Cardiovascular Diseases and Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.
Department of Nephrology and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, P.R. China.
Int J Mol Med. 2025 Oct;56(4). doi: 10.3892/ijmm.2025.5604. Epub 2025 Aug 1.
Atherosclerosis is a leading cause of cardiovascular diseases, causing significant morbidity and mortality. This review article examines the role of lactate and lactylation in atherosclerosis, a chronic inflammatory disease closely linked to lipid metabolism and immune system activation. Lactate, a metabolic byproduct and signaling molecule, has emerged as a key regulator of immune cell functions and epigenetic modifications. The article explores the mechanisms through which lactate and lactylation influence macrophage polarization, T‑cell differentiation and B‑cell metabolism, highlighting their complex dual roles in the progression of atherosclerosis. By modulating metabolic reprogramming, functional polarization and epigenetic regulation, lactate and lactylation significantly impact plaque formation and stability. These findings provide a foundation for developing novel therapeutic strategies targeting lactate metabolism and lactylation pathways.
动脉粥样硬化是心血管疾病的主要病因，会导致严重的发病率和死亡率。这篇综述文章探讨了乳酸和乳酸化在动脉粥样硬化中的作用，动脉粥样硬化是一种与脂质代谢和免疫系统激活密切相关的慢性炎症性疾病。乳酸作为一种代谢副产物和信号分子，已成为免疫细胞功能和表观遗传修饰的关键调节因子。本文探讨了乳酸和乳酸化影响巨噬细胞极化、T细胞分化和B细胞代谢的机制，强调了它们在动脉粥样硬化进展中的复杂双重作用。通过调节代谢重编程、功能极化和表观遗传调控，乳酸和乳酸化显著影响斑块的形成和稳定性。这些发现为开发针对乳酸代谢和乳酸化途径的新型治疗策略奠定了基础。
