揭开诊断之谜：小叶乳腺癌骨转移中F-FDG PET和骨扫描均为阴性：一例报告
Unveiling the Diagnostic Mystery: F-FDG PET and Bone Scan Negative in Bone Metastases of Lobular Breast Cancer: A Case Report.
作者信息
Usmani Sharjeel, Al Riyami Khulood, Jain Anjali, Al Busaidi Asiya, Dumasig Paul, Jayakrishnan Vipin V, Kheruka Subhash, Ahmed Najeeb
机构信息
Sultan Qaboos Comprehensive Cancer Care and Research Centre, Clinic of Radiology and Nuclear Medicine, Maskat, Oman.
Hull York Medical School, Faculty of Medicine; Castle Hill Hospital, Department of Radiology, Hill, Cottingham, UK.
出版信息
Mol Imaging Radionucl Ther. 2025 Aug 1. doi: 10.4274/mirt.galenos.2025.75875.
Identifying osseous metastases by imaging is essential and may be challenging in patients with lobular breast cancer. We present a case of a 66-year-old woman with lobular breast cancer who underwent F- fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) for staging purposes. F-FDG PET/CT reveals minimal FDG uptake in the primary tumor cells. Prominent sclerotic lesions with low FDG avidity are seen in the spinal and pelvic bones. The subsequent Tc-99m methylene diphosphonate bone scan is unremarkable. The magnetic resonance multiple imaging (MRI) reveals bone metastases. MRI may be beneficial in invasive lobular carcinoma. MRI facilitates improved metastatic evaluation, especially in bone-only and bone-predominant metastatic malignancies, when assessment with F-FDG PET/CT may be difficult and constrained.
通过影像学检查识别骨转移至关重要，但对于小叶型乳腺癌患者而言可能具有挑战性。我们报告一例66岁患有小叶型乳腺癌的女性患者，其接受了F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）以进行分期。FDG PET/CT显示原发肿瘤细胞中FDG摄取极少。在脊柱和骨盆骨中可见FDG摄取较低的显著硬化性病变。随后的锝-99m亚甲基二膦酸盐骨扫描未见异常。磁共振成像（MRI）显示存在骨转移。MRI对于浸润性小叶癌可能有益。当使用FDG PET/CT进行评估可能困难且受限的时候，MRI有助于改善对转移情况的评估，尤其是在仅发生骨转移和以骨转移为主的恶性肿瘤中。
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