Kazarian V A, Shitov G D, Rapoport E A
Biokhimiia. 1985 Aug;50(8):1305-11.
Using a radioindicator method, the metabolism of sarcoplasmic and myofibrillar proteins was studied in vivo at different stages of hypokinesia in rats. It was shown that the true muscle atrophy and the lowered content of both protein fractions during the first two weeks are due to sharp inhibition of sarcoplasmic protein biosynthesis as well as to deceleration of biosynthesis and acceleration of degradation of actomyosin. In hypokinesia the muscle mass does not increase within 3-8 weeks largely due to the acceleration of degradation of the de novo synthesized components of contractile proteins. In early hypokinesia a stressory mechanism plays an essential role in the pathogenesis of protein metabolism disturbances.
采用放射性示踪法，在大鼠运动功能减退的不同阶段，对其体内肌浆蛋白和肌原纤维蛋白的代谢进行了研究。结果表明，在前两周内，真正的肌肉萎缩以及两种蛋白质组分含量的降低，是由于肌浆蛋白生物合成的急剧抑制以及肌动球蛋白生物合成的减速和降解的加速。在运动功能减退期间，3 - 8周内肌肉质量未增加，这主要是由于收缩蛋白新合成成分降解的加速。在运动功能减退早期，应激机制在蛋白质代谢紊乱的发病机制中起重要作用。
