Markand O N
Neurology. 1977 Aug;27(8):746-57. doi: 10.1212/wnl.27.8.746.
Clinical features were studied in 83 patients with slow spike-wave activity in the EEG. Epileptic seizures, usually intractable, occurred in 82 patients. The majority had the onset of seizures during the first 2 years of life. Minor motor seizures alone or in combination with other types of seizures occurred in 80 percent, and most had more than one type of seizure. The combination of tonic-clonic, minor motor, and absence seizures was the commonest, occurring in 37 percent. Sixty-six patients were definitely retarded and 49 showed definite motor impairment. Etiologic factors responsible for cerebral insult were identified in 53 patients. Serial EEG studies showed a close relationship between the EEG patterns of hypsarrhythmia, independent multifocal spike discharges, and slow spike-wave activity. The eponym "Lennox-Gastaut" syndrome is appropriate for a patient who has slow spike-wave activity in the EEG, exhibits mental retardation, and has intractable seizures of various types. However, the syndrome does not imply a pathologic entity because many diverse processes, both static and progressive, can produce this syndrome.
对83例脑电图显示慢棘波活动的患者的临床特征进行了研究。82例患者出现癫痫发作，通常难以治疗。大多数患者在生命的头两年开始发作。单独或与其他类型发作合并出现的轻微运动性发作占80%，且大多数患者有不止一种发作类型。强直阵挛性、轻微运动性和失神发作合并出现最为常见，占37%。66例患者有明确的智力发育迟缓，49例有明确的运动障碍。在53例患者中确定了导致脑损伤的病因。系列脑电图研究显示，高峰失律、独立多灶性棘波放电和慢棘波活动的脑电图模式之间存在密切关系。“Lennox-Gastaut”综合征这一名称适用于脑电图有慢棘波活动、智力发育迟缓且有各种类型难治性发作的患者。然而，该综合征并不意味着是一种病理实体，因为许多不同的过程，包括静态和进行性的，都可导致此综合征。
