Collins P W, Twine J M
Br J Audiol. 1985 Nov;19(4):257-64. doi: 10.3109/03005368509078981.
The aims of this study were twofold: to obtain baseline data on gentamicin ototoxicity in the pigmented guinea pig, and to compare this data with an earlier study in the albino guinea pig. Animals were given ten consecutive daily doses, subcutaneously, of gentamicin at either 50, 75 or 100 mg/kg. Control animals received equivalent volumes of saline. After 3 weeks the animals were killed and their cochleae examined by light microscopy for hair cell damage. Hair cell damage was mapped onto cochleograms and subsequently quantified. Three sets of comparisons of hair cell damage were made: gentamicin group versus control group for each dose; comparisons between doses; pigmented animals versus albino animals. It was found that cochlear hair cell damage increased with increasing dose of gentamicin: 50 mg/kg was minimally ototoxic, 75 mg/kg was more ototoxic and 100 mg/kg was highly ototoxic, affecting a large extent of the spiral organ. There was a large (statistically significant) difference between the lower doses and the damage caused by 100 mg/kg. The pigmented-albino animal comparison showed albino guinea pigs to be more susceptible to gentamicin.
获取关于色素沉着豚鼠庆大霉素耳毒性的基线数据，并将该数据与早期对白化豚鼠的研究进行比较。给动物连续10天皮下注射50、75或100mg/kg的庆大霉素。对照动物注射等量的生理盐水。3周后处死动物，通过光学显微镜检查其耳蜗的毛细胞损伤情况。将毛细胞损伤情况绘制在耳蜗图上并随后进行量化。进行了三组毛细胞损伤比较：各剂量的庆大霉素组与对照组比较；不同剂量之间的比较；色素沉着动物与白化动物比较。结果发现，耳蜗毛细胞损伤随庆大霉素剂量增加而增加：50mg/kg耳毒性最小，75mg/kg耳毒性更大，100mg/kg耳毒性极高，影响螺旋器的范围很大。较低剂量与100mg/kg所致损伤之间存在很大（具有统计学意义）差异。色素沉着动物与白化动物的比较显示，白化豚鼠对庆大霉素更敏感。
