Barbosa Flávia Eduarda Vidal, de Alencar Granjeiro Yasmim, Roma Renato Rodrigues, da Silva Souza Racquel Oliveira, da Silva Cláudio Gleidiston Lima, Santos-Gomes Gabriela, da Fonseca Isabel Pereira, Teixeira Claudener Souza
Faculty of Medicine, Federal University of Cariri, CE, Brazil.
Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE, Brazil.
Int J Biol Macromol. 2025 Sep;321(Pt 3):146466. doi: 10.1016/j.ijbiomac.2025.146466. Epub 2025 Jul 30.
Lectins are natural proteins vital for organism survival, recognized for their specific carbohydrate-binding property. This unique characteristic enables diverse biotechnological applications, making them molecules of significant scientific interest. In this sense, hololectin DVL, a lectin found in the seeds of the fruit of the woody vine Dioclea violacea, has a multimeric structure that confers it several biological properties, including antinociceptive, entomotoxic, angiogenic, immunomodulatory, vasorelaxant, antibacterial, antiprotozoal and anti-inflammatory. However, their mechanisms of action remain largely unknown. This study aimed to review the available literature on the biological and structural properties of the lectin from Dioclea violacea, emphasizing its functions and properties that can be exploited through the mechanisms already proposed. This study reports the results of an integrative review based on 21 published articles selected from the databases of the National Library of Medicine (PubMed), Scientific Electronic Library Online (SciELO) and CAPES Periodicals Portal. Through the analysis of the selected studies, we conclude that, although the number of studies dedicated to DVL is still limited, this lectin represents a potential biological tool in several areas, either through its direct application through the mechanism of recognition of cell surface glycans or through its modulating capacity of other molecules.
凝集素是对生物体生存至关重要的天然蛋白质，因其具有特定的碳水化合物结合特性而闻名。这一独特特性使其具有多种生物技术应用，成为具有重大科学研究价值的分子。从这个意义上说，全凝集素DVL是一种存在于木质藤本植物紫花蝶豆果实种子中的凝集素，它具有多聚体结构，赋予其多种生物学特性，包括抗伤害感受、昆虫毒性、血管生成、免疫调节、血管舒张、抗菌、抗原生动物和抗炎特性。然而，其作用机制在很大程度上仍不为人知。本研究旨在综述有关紫花蝶豆凝集素生物学和结构特性的现有文献，重点关注其可通过已提出的机制加以利用的功能和特性。本研究报告了一项基于从美国国立医学图书馆（PubMed）、科学电子图书馆在线（SciELO）和巴西高等教育人员素质提升协调办公室期刊门户数据库中筛选出的21篇已发表文章的综合综述结果。通过对所选研究的分析，我们得出结论，尽管专门针对DVL的研究数量仍然有限，但这种凝集素在多个领域都代表着一种潜在的生物工具，无论是通过其对细胞表面聚糖的识别机制直接应用，还是通过其对其他分子的调节能力。
