Wang Zhiyan, Lai Yanbin, Zheng Bingde, Zhang Na, Yang Hongjie, Huang Yayan, Yang Yucheng, Zhang Xueqin, Ye Jing, Xiao Meitian
College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, China.
College of Chemical Engineering, Huaqiao University, Xiamen, Fujian 361021, China; Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Xiamen 361021, China.
Int J Biol Macromol. 2025 Sep;322(Pt 1):146382. doi: 10.1016/j.ijbiomac.2025.146382. Epub 2025 Jul 30.
Androgenetic alopecia (AGA), a prevalent form of hair loss, is typically treated with minoxidil and finasteride, but their efficacy and safety are somewhat constrained. Previous studies have shown that fucoidan can regulate VEGF and Wnt signaling pathways, which are critical for hair growth. Based on bioactivity screening protocols for natural product, we hypothesized that fucoidan may exert beneficial effects on AGA, potentially through modulation of the Wnt pathway and other molecular mechanisms. This study aimed to investigate the effect of fucoidan on testosterone propionate-induced AGA in mice and explore the underlying mechanisms, providing new insights into its therapeutic potential. The results demonstrated that 2 % fucoidan significantly alleviated AGA symptoms, promoted hair growth, and increased hair density. Mechanistically, fucoidan ameliorated testosterone propionate-induced hair follicle (HF) atrophy and developmental arrest, while restoring HF pigmentation. Further analysis revealed that fucoidan regulated the Wnt/β-catenin signaling pathway, reduced cellular apoptosis, and promoted the release of vascular endothelial growth factor (VEGF). Additionally, fucoidan effectively reduced microinflammation in AGA-afflicted mice. Collectively, these findings suggest that fucoidan has potential therapeutic effects against AGA.
雄激素性脱发（AGA）是一种常见的脱发形式，通常用米诺地尔和非那雄胺治疗，但其疗效和安全性存在一定局限。先前的研究表明，岩藻多糖可调节对毛发生长至关重要的血管内皮生长因子（VEGF）和Wnt信号通路。基于天然产物的生物活性筛选方案，我们推测岩藻多糖可能对AGA产生有益作用，可能是通过调节Wnt通路及其他分子机制实现的。本研究旨在探讨岩藻多糖对丙酸睾酮诱导的小鼠AGA的影响，并探究其潜在机制，为其治疗潜力提供新的见解。结果表明，2%的岩藻多糖显著减轻了AGA症状，促进了头发生长，并增加了毛发密度。从机制上讲，岩藻多糖改善了丙酸睾酮诱导的毛囊萎缩和发育停滞，同时恢复了毛囊色素沉着。进一步分析发现，岩藻多糖调节Wnt/β-连环蛋白信号通路，减少细胞凋亡，并促进血管内皮生长因子（VEGF）的释放。此外，岩藻多糖有效减轻了AGA患病小鼠的微炎症。总体而言，这些发现表明岩藻多糖对AGA具有潜在的治疗作用。
