William Jeremy, Ferreira Luigi Zanetti, Voskoboinik Aleksandr, Chieng David, Mariani Justin A, Patel Hitesh
The Alfred Hospital, Melbourne, Victoria, Australia; Monash University, Melbourne, Victoria, Australia; The Baker Heart and Diabetes Research Institute, Melbourne, Victoria, Australia.
Monash University, Melbourne, Victoria, Australia.
JACC Case Rep. 2025 Jul 30;30(21):104157. doi: 10.1016/j.jaccas.2025.104157.
Coronary vasospasm (CV) is a rare cause of malignant ventricular arrhythmia and cardiac arrest. It typically presents with chest pain and marked ST-segment elevation.
We present the case of a 61-year-old man with recurrent malignant ventricular arrhythmia and implantable defibrillator shocks without preceding chest pain. The diagnosis of CV remained elusive for 3 months despite extensive investigation. Close inspection of telemetry revealed progressive ST-segment depression and T-wave inversion before arrest. Coronary angiography with low-dose acetylcholine testing revealed multivessel vasospasm. Vasodilator therapy was initiated with rapid elimination of ventricular arrhythmia.
This case highlights that cardiac arrest due to CV may present without the classical features of chest pain or ST-segment elevation, underscoring the value of provocation testing in unexplained arrhythmia.
TAKE-HOME MESSAGES: CV may present without preceding angina or ST-segment elevation. Careful electrocardiogram review and early provocation testing can identify vasospasm and guide therapy.
冠状动脉痉挛(CV)是恶性室性心律失常和心脏骤停的罕见原因。其典型表现为胸痛和明显的ST段抬高。
我们报告一例61岁男性,反复发生恶性室性心律失常且植入式除颤器多次电击,无前驱胸痛。尽管进行了广泛检查,但3个月来CV的诊断仍不明确。对遥测数据的仔细检查显示,心脏骤停前ST段逐渐压低和T波倒置。冠状动脉造影及低剂量乙酰胆碱试验显示多支血管痉挛。开始使用血管扩张剂治疗后,室性心律失常迅速消除。
该病例突出表明,CV所致心脏骤停可能不具有胸痛或ST段抬高的典型特征,强调了激发试验在不明原因心律失常中的价值。
CV可能无前驱心绞痛或ST段抬高。仔细回顾心电图和早期激发试验可识别血管痉挛并指导治疗。