Ding Lin, Lin Xiaojing, Pan Peipei, Li Yan, Chen Wei, He Liying, Xu Yunsheng, Chang Hsun-Ming, Yang Haiyan, Wang Guiquan, Mu Liangshan
Post-doctoral Mobile Research Station, Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
J Diabetes. 2025 Aug;17(8):e70132. doi: 10.1111/1753-0407.70132.
Whether diverse metabolic statuses within a similar body mass index (BMI) category associate with different in vitro fertilization (IVF) outcomes.
A retrospective cohort study.
Wenzhou, Zhengjiang Province, China.
This retrospective cohort study prescreened 16 458 women who underwent their first IVF and fresh embryo transfer cycle between January 2010 and December 2021.
Metabolic status was assessed using the National Cholesterol Education Program-Adult Treatment Panel III criteria. Patients were then categorized into six groups: metabolically healthy normal weight, metabolically unhealthy normal weight, metabolically healthy overweight, metabolically unhealthy overweight, metabolically healthy obese, and metabolically unhealthy obese.
The primary outcome was live birth rate.
Regarding live birth, rates in normal weight women were initially lower for metabolically unhealthy normal weight versus metabolically healthy normal weight (44.6% vs. 48.6%), but this was not significant after multivariate adjustment. In obese women, live birth rates were similar between metabolically unhealthy obese and metabolically healthy obese (41.5% vs. 43.9%), with no adjusted difference. For secondary outcomes, metabolically unhealthy normal weight patients had lower biochemical pregnancy rates than metabolically healthy normal weight (OR: 0.86, 95% CI: 0.76-0.98); high blood pressure was a significant risk factor for this outcome in metabolically unhealthy normal weight (OR: 0.84, 95% CI: 0.72-0.98).
Our findings indicated that different cardio-metabolic risk factors but a similar BMI category may have limited adverse effects on live birth rate.
在相似的体重指数（BMI）类别中，不同的代谢状态是否与不同的体外受精（IVF）结局相关。
一项回顾性队列研究。
中国浙江省温州市。
这项回顾性队列研究对2010年1月至2021年12月期间接受首次IVF和新鲜胚胎移植周期的16458名女性进行了预先筛选。
使用美国国家胆固醇教育计划成人治疗小组第三次报告标准评估代谢状态。然后将患者分为六组：代谢健康的正常体重组、代谢不健康的正常体重组、代谢健康的超重组、代谢不健康的超重组、代谢健康的肥胖组和代谢不健康的肥胖组。
主要结局为活产率。
关于活产，代谢不健康的正常体重女性的活产率最初低于代谢健康的正常体重女性（44.6%对48.6%），但多变量调整后差异无统计学意义。在肥胖女性中，代谢不健康的肥胖组和代谢健康的肥胖组的活产率相似（41.5%对43.9%），调整后无差异。对于次要结局，代谢不健康的正常体重患者的生化妊娠率低于代谢健康的正常体重患者（OR：0.86，95%CI：0.76-0.98）；高血压是代谢不健康的正常体重患者出现此结局的显著危险因素（OR：0.84，95%CI：0.72-0.98）。
我们的研究结果表明，不同的心血管代谢危险因素但BMI类别相似可能对活产率产生有限的不良影响。
