Moon Sung Min, Kim Jaehoon, Seol Jaeheon, Yang Seonguk, Jung Duwon, Kim Chang Yup, Kim Chang Seok, Chung Ki Wung, Jung Young-Suk, Chang Seung-Cheol, Chung Hae Young, Lee Jaewon
College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.
Research Institute for Drug Development, Pusan National University, Busan, 46241, Republic of Korea.
Arch Pharm Res. 2025 Aug;48(7-8):814-829. doi: 10.1007/s12272-025-01563-z. Epub 2025 Aug 2.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons due to oxidative stress and inflammation. Targeting inflammation and oxidative stress offers a promising means of slowing PD progression. Taurine, a naturally occurring amino sulfonic acid, has demonstrated potent antioxidant properties, thereby preventing cell death. While taurine has been studied for its potential to restrain the progression of Alzheimer's disease and mitigate microglial activation, its impact on astrocyte activation in PD models remains underexplored. Here, we found that taurine significantly reduces astroglial activation in MPP-induced primary astrocytes by inhibiting the NF-κB pathway. Additionally, in vivo experiments in MPTP-induced PD models using male C57BL/6 mice showed that taurine improved motor function, protected against dopaminergic neuronal loss, and reduced glial activation in the striatum and substantia nigra. These findings highlight that the anti-inflammatory effects of taurine involve the inhibition of astroglial activation, suggesting that taurine has therapeutic potential in PD.
帕金森病（PD）是一种神经退行性疾病，其特征是由于氧化应激和炎症导致多巴胺能神经元丧失。针对炎症和氧化应激为减缓PD进展提供了一种有前景的方法。牛磺酸是一种天然存在的氨基磺酸，已显示出强大的抗氧化特性，从而防止细胞死亡。虽然已经研究了牛磺酸抑制阿尔茨海默病进展和减轻小胶质细胞活化的潜力，但其对PD模型中星形胶质细胞活化的影响仍未得到充分研究。在这里，我们发现牛磺酸通过抑制NF-κB途径显著降低MPP诱导的原代星形胶质细胞中的星形胶质细胞活化。此外，在使用雄性C57BL/6小鼠的MPTP诱导的PD模型中的体内实验表明，牛磺酸改善了运动功能，防止多巴胺能神经元丧失，并减少了纹状体和黑质中的胶质细胞活化。这些发现突出表明牛磺酸的抗炎作用涉及抑制星形胶质细胞活化，表明牛磺酸在PD中具有治疗潜力。
