Tuğral Alper, Arıbaş Zeynep, Kaya Uçar Gözde, Arslan Fatma Demet, Bakar Yeşim, Karakoyun Inanç, Akyol Murat
Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Izmir Bakırçay University, Izmir, Turkey.
Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Trakya University, Edirne, Turkey.
Support Care Cancer. 2025 Aug 2;33(8):741. doi: 10.1007/s00520-025-09788-w.
This prospective study is aimed at assessing the effect of aerobic exercise on adipokine and myokine biomarkers of breast or colon cancer patients during chemotherapy.
Thirty-two patients (15 exercise, 17 control) were included in this study. In total, 27 out of 32 and 26 out of 32 patients were female and diagnosed with breast cancer, respectively. The exercise protocol was performed via stationary resistive cycle ergometer during chemotherapy 2 times each week for at least 12 weeks. Circulating serum biomarkers of IL-6, irisin, leptin, and adiponectin levels were measured before chemotherapy and after the last chemotherapy cycle. The intensity of exercise was set as submaximal (50-70% of heart rate reserve (HRR)). Each patient was started with the intensity of exercise at the rate of 50% of their maximal HR. Each supervised exercise session lasted for 35 min.
The mean exercise duration (weeks) and percent adherence rates in the EG were 19.20 ± 3.63 weeks and 85.13 ± 11.87, respectively. In EG, there were significant increases in IL-6 (t = - 2.985, p = 0.011) and adiponectin (z = - 2.229, p = 0.026). Although a nearly 10% increase was observed in Irisin levels (0.83 vs. 0.91), it did not reach statistical significance (t = 0.840, p = 0.416). In EG, the correlation between Δ of leptin and adiponectin (r = - 0.635, p = 0.015) and the correlation between Δ of leptin and irisin (r = 0.802, p = 0.001) were found significant. No significant change was observed in each biomarker for CG.
This study demonstrated that aerobic exercise can be safely implementable and beneficial during chemotherapy with significant effects on anti-inflammatory biomarkers via increased levels of IL-6 and adiponectin.
NCT07048847, date of registration: 02.07.2025, "retrospectively registered".
本前瞻性研究旨在评估有氧运动对乳腺癌或结肠癌患者化疗期间脂肪因子和肌动蛋白生物标志物的影响。
本研究纳入了32例患者（15例运动组，17例对照组）。32例患者中分别有27例和26例为女性，且被诊断为乳腺癌。运动方案在化疗期间通过固定阻力自行车测力计进行，每周2次，至少持续12周。在化疗前和最后一个化疗周期后测量循环血清中白细胞介素-6（IL-6）、鸢尾素、瘦素和脂联素水平的生物标志物。运动强度设定为次最大强度（心率储备（HRR）的50%-70%）。每位患者从其最大心率的50%开始运动强度。每次有监督的运动 session 持续35分钟。
运动组的平均运动持续时间（周）和依从率分别为19.20±3.63周和85.13±11.87。在运动组中，IL-6（t=-2.985，p=0.011）和脂联素（z=-2.229，p=0.026）有显著增加。尽管鸢尾素水平观察到近10%的增加（0.83对0.91），但未达到统计学意义（t=0.840，p=0.416）。在运动组中，发现瘦素和脂联素的变化量之间的相关性（r=-0.635，p=0.015）以及瘦素和鸢尾素的变化量之间的相关性（r=0.802，p=0.001）显著。对照组的每种生物标志物均未观察到显著变化。
本研究表明，有氧运动在化疗期间可以安全实施且有益，通过增加IL-6和脂联素水平，对抗炎生物标志物有显著影响。
NCT07048847，注册日期：2025年7月2日，“回顾性注册”
