Tu Dingyuan, Ju Shuhui, Xue Yu, Xie Weijuan, Wu Cong, Ma Chaoqun, Xu Qiang
Department of Cardiology, The 961th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Qiqihar, 161000, China.
Department of Thyroid and Breast Surgery, Naval Medical Center of PLA, Naval Medical University, Shanghai, 200052, China.
Respir Med. 2025 Aug 2;247:108288. doi: 10.1016/j.rmed.2025.108288.
In 2023, the American Heart Association presented a new condition, cardiovascular-kidney-metabolic (CKM) syndrome, recognized for its multistage and multisystem nature. Given that inflammatory condition can enhance the risk for CKM syndrome and asthma is a disease characterized by chronic airway inflammation, asthma could potentially increase the progression through CKM syndrome stages. The aim of the present study was to investigate the association between asthma and advanced CKM syndrome.
This cross-sectional study used data on U.S. adults from the National Health and Nutrition Examination Survey 2011-2023. Participants were categorized into five CKM stages (0-4) according to the clinical severity of CKM syndrome. CKM syndrome was defined as stage 1 or above, with advanced stages being stage 3 or 4. Self-administered questionnaires were used to collect information on asthma. Multivariable weighted logistic regression models were used to analyze the relationship between asthma and the prevalence of advanced CKM syndrome.
A total of 22,394 CKM syndrome patients were included in the final analysis, of which 3610 were categorized into advanced CKM syndrome, while the remaining 18,784 were not. After adjusting confounding covariates, asthma was associated with advanced CKM syndrome (odds ratio, 1.86; 95 % confidence interval, 1.59-2.18; p < 0.0001). Further subgroup and sensitivity analyses showed consistent results.
In this cross-sectional study, asthma was positively associated with advanced CKM syndrome in the U.S. adult population. These findings highlight the significance of considering asthma as a risk-enhancing factor for advanced CKM syndrome stages prevention.
2023年，美国心脏协会提出了一种新病症，即心血管-肾脏-代谢（CKM）综合征，其具有多阶段和多系统的特点。鉴于炎症状态会增加CKM综合征的风险，而哮喘是以慢性气道炎症为特征的疾病，哮喘可能会加速CKM综合征各阶段的进展。本研究的目的是调查哮喘与晚期CKM综合征之间的关联。
这项横断面研究使用了2011 - 2023年美国国家健康与营养检查调查中美国成年人的数据。根据CKM综合征的临床严重程度，将参与者分为五个CKM阶段（0 - 4）。CKM综合征定义为1期及以上，晚期为3期或4期。通过自行填写问卷收集哮喘相关信息。使用多变量加权逻辑回归模型分析哮喘与晚期CKM综合征患病率之间的关系。
最终分析共纳入22394例CKM综合征患者，其中3610例被归类为晚期CKM综合征，其余18784例未被归类。在调整混杂协变量后，哮喘与晚期CKM综合征相关（优势比为1.86；95%置信区间为1.59 - 2.18；p < 0.0001）。进一步的亚组分析和敏感性分析结果一致。
在这项横断面研究中，在美国成年人群中，哮喘与晚期CKM综合征呈正相关。这些发现凸显了将哮喘视为晚期CKM综合征阶段预防的风险增强因素的重要性。
