Bezard Erwan, Anderson Rozalyn M, Badin Romina Aron, Bergman Hagai, Boehringer Ashley, Borgognon Simon, Emborg Marina E, Kordower Jeffrey H, Li Jia-Yi, Martel Anne-Caroline, Metzger Jeanette M, Smith Yoland, Takada Masahiko, Takahashi Jun, Takahashi Ryosuke, Dehay Benjamin
Univ. Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.
Division of Geriatrics, Department of Medicine, SMPH, University of Wisconsin-Madison, & GRECC, William S Middleton Memorial Veterans Hospital, Madison, WI, USA.
NPJ Parkinsons Dis. 2025 Aug 2;11(1):227. doi: 10.1038/s41531-025-01088-8.
The PD-AGE international task force underscores the pivotal role that non-human primate (NHP) models play in advancing our understanding of Parkinson's disease (PD) and ageing. Due to their close genetic, anatomical, and behavioural similarity to humans, NHPs uniquely enable translational research to bridge basic science towards clinical application. They are indispensable for modelling the complex motor and non-motor symptoms of PD, as well as age-related neurodegeneration. This paper outlines the scientific rationale, methodological strengths, and ethical considerations surrounding NHP use in PD research. We highlight the need for standardised models, innovative tools, and long-term collaborative infrastructure to enhance the translational value of NHP studies. We propose a three-phase roadmap to develop a global research consortium to optimise resource use, improve model fidelity, and accelerate therapeutic development for PD and related neurodegenerative disorders.
帕金森病与衰老国际特别工作组强调了非人灵长类动物（NHP）模型在增进我们对帕金森病（PD）和衰老的理解方面所发挥的关键作用。由于它们在基因、解剖结构和行为上与人类高度相似，非人灵长类动物为将基础科学转化为临床应用的转化研究提供了独特的条件。它们对于模拟帕金森病复杂的运动和非运动症状以及与年龄相关的神经退行性变至关重要。本文概述了在帕金森病研究中使用非人灵长类动物的科学依据、方法优势和伦理考量。我们强调需要标准化模型、创新工具和长期协作基础设施，以提高非人灵长类动物研究的转化价值。我们提出了一个三阶段路线图，以建立一个全球研究联盟，优化资源利用，提高模型保真度，并加速针对帕金森病及相关神经退行性疾病的治疗开发。
