Abdul-Latif Sulemana, Yorke Joseph, Brenu Samuel Gyasi, Oppong Joseph Kwaku, Buckman Tonnies Abeku, Aitpillah Francis Somiah-Kwao, Laryea Jonathan, Kwakye Gifty, Adinku Michael Ofoe, Gyamfi Frank Enoch, Agbedinu Kwabena, Yamoah Francis Akwaw, Kyei Ishmael, Mensah Samuel, Dally Charles Kofi, Agbeko Anita Eseenam, Darkwa Dominic Akuoku, Bosompem Kingsley, Yorke Dennis Afful, Agyapong Akwasi Opoku, Oppong-Nkrumah Nana Akosua, Adjei Martin Kofi, Ellis Theodora-Ann Fremponma, Sam-Awortwi Jnr Wilfred, Baffowa Yaa Takyi
Directorate of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Department of Surgery, Kwame Nkrumah University of Science and Technology, KNUST, Kumasi, Ghana.
BMC Surg. 2025 Aug 2;25(1):334. doi: 10.1186/s12893-025-03088-0.
and Aims: Surgical site infection (SSI) remains a common postoperative complication for patients with acute appendicitis. This study aimed to compare the effectiveness of dilute povidone-iodine and normal saline in preventing post-appendectomy surgical site infections.
The study included 224 consecutive patients who underwent open appendectomy for acute appendicitis between October 2020 and December 2021 at Komfo Anokye Teaching Hospital in Ghana. Patients were randomly assigned to have irrigation with either povidone iodine or normal saline after appendectomy. The surgical wounds were assessed for infection using the Southampton wound grading system at 5 days post-surgery till 30 days.
The mean age of the patients was 30.8 ± 14.4 years. The overall incidence of SSI was 8.04% (10.7% in the N/S group and 5.4% in the PI group). Both groups had a higher percentage of male patients (58% in the N/S group and 58.9% in the PI group). The mean length of hospital stays for patients with and without SSI was 10.11 ± 5.06 days and 4.69 ± 2.07 days respectively. The mean length of stay for the N/S group and PI group patients was 5.25 ± 2.95 days and 5.02 ± 2.81 days respectively. The mean cost for patients with and without SSI was GHC3,813.64(US$238.3) and GHC2,364.45 (US$147.7) respectively.
We conclude that there was no difference in SSI rates when comparing normal saline and povidone-iodine as irrigant fluids in patients undergoing an open appendectomy.
手术部位感染（SSI）仍是急性阑尾炎患者常见的术后并发症。本研究旨在比较稀聚维酮碘和生理盐水在预防阑尾切除术后手术部位感染方面的效果。
该研究纳入了2020年10月至2021年12月期间在加纳的孔福·阿诺凯教学医院接受急性阑尾炎开腹阑尾切除术的224例连续患者。患者在阑尾切除术后被随机分配用聚维酮碘或生理盐水冲洗。术后5天至30天，使用南安普顿伤口分级系统评估手术伤口是否感染。
患者的平均年龄为30.8±14.4岁。SSI的总体发生率为8.04%（生理盐水组为10.7%，聚维酮碘组为5.4%）。两组男性患者比例均较高（生理盐水组为58%，聚维酮碘组为58.9%）。发生SSI和未发生SSI的患者平均住院时间分别为10.11±5.06天和4.69±2.07天。生理盐水组和聚维酮碘组患者的平均住院时间分别为5.25±2.95天和5.02±2.81天。发生SSI和未发生SSI的患者平均费用分别为3813.64加纳塞地（238.3美元）和2364.45加纳塞地（147.7美元）。
我们得出结论，在接受开腹阑尾切除术的患者中，比较生理盐水和聚维酮碘作为冲洗液时，SSI发生率没有差异。
