Li Xiaoping, He Yang, Lu Xin, Dai Shouqian, Xu Feng, Yang Peng
Department of Emergency Medicine, First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Gusu District, Soochow, Jiangsu, 215006, PR China.
BMC Anesthesiol. 2025 Aug 2;25(1):391. doi: 10.1186/s12871-025-03222-8.
Sepsis is a life-threatening organ dysfunction. To explore the predictive value of platelet parameters and hemorheological indicators for mortality risk in elderly sepsis patients. The clinical data of 86 elderly patients with sepsis admitted to the intensive care unit of our hospital from June 2020 to June 2023 were retrospectively analyzed. According to the survival outcome, the patients were divided into the death group (28 cases) and the survival group (58 cases). The platelet parameters and hemorheological indicators of the two groups were compared. Pearson correlation analysis was used to analyze platelet parameters, hemorheology and Sequential Organ Failure Assessment (SOFA). Patients in the death group had higher APACHE II score, SOFA score, MPV, plasma viscosity, Equation K Value of ESR, and RDW than those in the survival group (P < 0.05). SOFA score was positively correlated with MPV, plasma viscosity, Equation K Value of ESR and RDW (P < 0.05), but not correlated with PLT and PDW (P < 0.05). APACHE II score, SOFA score, MPV, plasma viscosity, Equation K Value of ESR, and RDW were risk factors for mortality in elderly sepsis patients (P < 0.05). The joint prediction had higher performance than individual indicator (all P < 0.05). MPV, plasma viscosity, equation K value of ESR, and RDW were related to multiple organ failure in elderly sepsis patients, and could be used to predict the risk of death in patients, with good predictive performance.
脓毒症是一种危及生命的器官功能障碍。为探讨血小板参数和血液流变学指标对老年脓毒症患者死亡风险的预测价值。回顾性分析了2020年6月至2023年6月我院重症监护病房收治的86例老年脓毒症患者的临床资料。根据生存结局，将患者分为死亡组（28例）和生存组（58例）。比较两组的血小板参数和血液流变学指标。采用Pearson相关分析血小板参数、血液流变学与序贯器官衰竭评估（SOFA）。死亡组患者的APACHE II评分、SOFA评分、平均血小板体积（MPV）、血浆黏度、红细胞沉降率（ESR）方程K值和红细胞分布宽度（RDW）均高于生存组（P＜0.05）。SOFA评分与MPV、血浆黏度、ESR方程K值和RDW呈正相关（P＜0.05），但与血小板计数（PLT）和血小板分布宽度（PDW）无相关性（P＞0.05）。APACHE II评分、SOFA评分、MPV、血浆黏度、ESR方程K值和RDW是老年脓毒症患者死亡的危险因素（P＜0.05）。联合预测的性能优于单个指标（均P＜0.05）。MPV、血浆黏度ESR方程K值和RDW与老年脓毒症患者多器官衰竭有关，可用于预测患者死亡风险，预测性能良好。
